methoxysulfonylmethylbenzene

Base Information

• Chemical Name: methoxysulfonylmethylbenzene
• CAS No.: 5877-96-3
• Molecular Formula: C8H10O3S
• Molecular Weight: 186.232
• Mol file: 5877-96-3.mol

Synonyms:

Chemical Property of methoxysulfonylmethylbenzene

Chemical Property:

• Boiling Point: 341.8°Cat760mmHg
• Flash Point: 160.5°C
• Density: 1.244g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methoxysulfonylmethylbenzene

There total 6 articles about methoxysulfonylmethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methanol (67-56-1) + benzenesulfonyl chloride (1939-99-7) → methyl α-phenylmethanesulfonate (5877-96-3)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1021/ja00006a052

Reference yield: 15.0%

methanol (67-56-1) + p-toluidine (106-49-0,12221-03-3) + benzenesulfonyl chloride (1939-99-7) → methyl α-phenylmethanesulfonate (5877-96-3) + phenylmethanesulfon-p-toluidide (5434-03-7)

Guidance literature:

at 45 ℃; for 0.0166667h; Product distribution; Mechanism; further reaction time;

DOI:10.1016/S0040-4039(00)96680-2

Reference yield:

sodium methylate (124-41-4) + benzenesulfonyl chloride (1939-99-7) → methyl α-phenylmethanesulfonate (5877-96-3)

Guidance literature:

In methanol; dichloromethane; at 0 - 20 ℃;

DOI:10.1021/acs.orglett.7b01021

upstream raw materials:

methanol

benzenesulfonyl chloride

p-toluidine

deuteromethanol

Downstream raw materials:

(S)-(-)-1-phenylethanesulfonic acid

(R)-1-phenylethanesulfonic acid

Refernces

• 1、 Koh, Han Joong,Kang, Suk Jin. "Application of the extended Grunwald-Winstein equation to the solvolyses of phenyl methanesulfonyl chloride in aqueous binary mixtures". experimental part. p. 1897 - 1901. Retrieved 2012/01/14.
• 2、 Zhong, Ziyang,Bibbs, Jeffrey A.,Yuan, Wei,Wong, Chi-Huey. "Active-Site-Directed Modification of Subtilisin". . p. 2259 - 2263. Retrieved 2007/10/02.