1-Phenylimidazole

Base Information

• Chemical Name: 1-Phenylimidazole
• CAS No.: 7164-98-9
• Molecular Formula: C9H8N2
• Molecular Weight: 144.176
• Hs Code.: 2933290090
• Mol file: 7164-98-9.mol

Synonyms:N-Phenylimidazole;Phenylimidazole;

Chemical Property of 1-Phenylimidazole

Chemical Property:

• Appearance/Colour: clear light yellow to yellow liquid
• Vapor Pressure: 0.00829mmHg at 25°C
• Melting Point: 13 °C(lit.)
• Refractive Index: 1.599-1.601
• Boiling Point: 276 °C at 760 mmHg
• PKA: 5.45±0.10(Predicted)
• Flash Point: 120.7 °C
• PSA: 17.82000
• Density: 1.06 g/cm³
• LogP: 1.87230
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Phenyl-1H-imidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 1-Phenylimidazole is a suitable reagent used to investigate its effect on the citrulline formation by bovine brain nitric-oxide synthase.

Technology Process of 1-Phenylimidazole

There total 54 articles about 1-Phenylimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1H-imidazole (288-32-4) + phenylboronic acid (98-80-6) → 1-phenylimidazole (7164-98-9)

Guidance literature:

With [Cu₄I₄(1,4-diazabicyclo[2.2.2]octane)₂]_n; In methanol; at 27 ℃; for 5h;

DOI:10.1016/j.tetlet.2014.07.118

Reference yield: 100.0%

1H-imidazole (288-32-4) + iodobenzene (591-50-4) → 1-phenylimidazole (7164-98-9)

Guidance literature:

With potassium tert-butylate; copper(I) oxide; In N,N-dimethyl-formamide; at 80 ℃; for 24h;

DOI:10.1016/j.tetlet.2008.05.008

Reference yield: 99.0%

1H-imidazole (288-32-4) + bromobenzene (108-86-1,52753-63-6) → 1-phenylimidazole (7164-98-9)

Guidance literature:

With potassium carbonate; copper(l) chloride; In 1-methyl-pyrrolidin-2-one; at 130 ℃; for 16h;

DOI:10.1055/s-2006-951510

upstream raw materials:

1,3-oxazole-4-carboxylic acid

aniline

1-phenylpyrazole

1H-imidazole

Downstream raw materials:

{Cu(C₁₀H₇N₂O₂)2}

C₁₈H₁₄B₂N₄(C₉H₁₁)4

fac-tricarbonyltris(N-phenylimidazole)rhenium(I) tetrakis(3,5-bis(trifluoromethyl)phenyl)borate

1-(2,4-dinitrophenyl)-3-phenylimidazolium chloride

Refernces

• 1、 Bukowska, Agnieszka,Bukowski, Wiktor,Bester, Karol,Hus, Krzysztof. "Polymer supported copper(II) amine-imine complexes in the C-N and A3 coupling reactions". . . Retrieved 2017.
• 2、 Collman,Zhong,Zhang,Costanzo. "Catalytic activities of Cu(II) complexes with nitrogen-chelating bidentate ligands in the coupling of imidazoles with arylboronic Acids". . p. 7892 - 7897. Retrieved 2001.
• 3、 Zhang, Maoyuan,Xu, Zengbing,Shi, Dabin. "Cu(I)–N-heterocyclic carbene-catalyzed base free C–N bond formation of arylboronic acids with amines and azoles". . . Retrieved 2020/12/25.
• 4、 Venkateswarlu, Katta,Rao, Kanusu Umamaheswara. "Cu(OAc)2-porphyrins as an efficient catalytic system for base-free, nature mimicking Chan–Lam coupling in water". . . Retrieved 2021/03/03.