Pindolol

Base Information Edit

Chemical Name:Pindolol
CAS No.:13523-86-9
Deprecated CAS:21870-06-4
Molecular Formula:C14H20N2O2
Molecular Weight:248.325
Hs Code.:2933995300
European Community (EC) Number:236-867-9
NSC Number:757276
UNII:BJ4HF6IU1D
DSSTox Substance ID:DTXSID8023476
Nikkaji Number:J457.020K,J246.149H,J3.439H
Wikipedia:Pindolol
Wikidata:Q418101
NCI Thesaurus Code:C47673
RXCUI:8332
Pharos Ligand ID:RM344THTUMNV
Metabolomics Workbench ID:145689
ChEMBL ID:CHEMBL500
Mol file:13523-86-9.mol

Synonyms:LB 46;LB-46;LB46;Pindolol;Prindolol;Visken

Suppliers and Price of Pindolol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Pindolol
100mg
$ 296.00

TRC
Pindolol
100mg
$ 105.00

Sigma-Aldrich
Pindolol United States Pharmacopeia (USP) Reference Standard
200mg
$ 366.00

Sigma-Aldrich
Pindolol ≥98% (TLC), powder
1g
$ 107.00

Sigma-Aldrich
Pindolol European Pharmacopoeia (EP) Reference Standard
$ 190.00

Sigma-Aldrich
Pindolol European Pharmacopoeia (EP) Reference Standard
p1800000
$ 190.00

Sigma-Aldrich
Pindolol ≥98% (TLC), powder
250mg
$ 78.60

ChemScene
Pindolol 99.91%
100mg
$ 60.00

Cayman Chemical
Pindolol ≥99%
250mg
$ 131.00

Cayman Chemical
Pindolol ≥99%
500mg
$ 232.00

Total 47 raw suppliers

Chemical Property of Pindolol Edit

Chemical Property:

Appearance/Colour:white to off-white crystalline powder
Vapor Pressure:3.77E-09mmHg at 25°C
Melting Point:167-171 °C(lit.)
Refractive Index:1.5110 (estimate)
Boiling Point:457.132 °C at 760 mmHg
PKA:pKa 9.26 (Uncertain)
Flash Point:230.265 °C
PSA：57.28000
Density:1.152 g/cm³
LogP:2.29650
Storage Temp.:2-8°C
Solubility.:0.1 M NaOH: 0.2 mg/mL
Water Solubility.:33mg/L(22.5 oC)
XLogP3:1.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:248.152477885
Heavy Atom Count:18
Complexity:248

Purity/Quality:

99% ^*data from raw suppliers

Pindolol ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-36/37/38
Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Drug Classes:Beta-Adrenergic Receptor Antagonists
Canonical SMILES:CC(C)NCC(COC1=CC=CC2=C1C=CN2)O
Recent ClinicalTrials:Study of Human Non-Shivering Thermogenesis and Basal Metabolic Rate
Recent EU Clinical Trials:Intensiv ikke-sympatikus aktiverende vasodilaterende behandling hos patienter med mikrovaskul?r angina pectoris
Uses Mixed β-adrenergic blocker and serotonin 5HT1A-receptor antagonist. Antihypertensive; antianginal; antiarrhythmic; antiglaucoma. Pindolol, like nadolol, is a nonselective β-adrenoblocker. It possesses antianginal, antihypotensive, and antiarrythmic action. It is used for arterial hypertension, angina stress (preventing attacks), supraventricular tachycardia, tachsystolic form of atrial fibrillation, and superventricular extrasystole.
Therapeutic Function Beta-adrenergic blocker
Clinical Use Beta-blocker: Hypertension Angina
Drug interactions Potentially hazardous interactions with other drugs Anaesthetics: enhanced hypotensive effect. Analgesics: NSAIDs antagonise hypotensive effect. Anti-arrhythmics: increased risk of myocardial depression and bradycardia; increased risk of bradycardia, myocardial depression and AV block with amiodarone; increased risk of myocardial depression and bradycardia with flecainide. Antidepressants: enhanced hypotensive effect with MAOIs. Antihypertensives; enhanced hypotensive effect; increased risk of withdrawal hypertension with clonidine; increased risk of first dose hypotensive effect with post-synaptic alpha-blockers such as prazosin. Antimalarials: increased risk of bradycardia with mefloquine. Antipsychotics: enhanced hypotensive effect with phenothiazines. Calcium-channel blockers: increased risk of bradycardia and AV block with diltiazem; hypotension and heart failure possible with nifedipine and nisoldipine; asystole, severe hypotension and heart failure with verapamil. Cytotoxics: possible increased risk of bradycardia with crizotinib. Diuretics: enhanced hypotensive effect. Fingolimod: possibly increased risk of bradycardia. Moxisylyte: possible severe postural hypotension. Sympathomimetics: severe hypertension with adrenaline and noradrenaline and possibly with dobutamine.

Technology Process of Pindolol

There total 16 articles about Pindolol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%