Quinoline, 3-iodo-4-phenyl-

Base Information

• Chemical Name: Quinoline, 3-iodo-4-phenyl-
• CAS No.: 809274-63-3
• Molecular Formula: C15H10IN
• Molecular Weight: 331.156
• Mol file: 809274-63-3.mol

Synonyms:

Chemical Property of Quinoline, 3-iodo-4-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Quinoline, 3-iodo-4-phenyl-

There total 14 articles about Quinoline, 3-iodo-4-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-iodo-1-methanesulfonyl-4-phenyl-1,2-dihydroquinoline (809274-74-6) → 3-iodo-4-phenylquinoline (809274-63-3)

Guidance literature:

With sodium hydroxide; oxygen; In ethanol; at 50 ℃; for 12h; under 760 Torr;

DOI:10.1021/ol0476218 DOI:10.1021/jo048788h

Reference yield: 86.0%

N-(3-phenylprop-2-ynyl)benzenamine (121194-51-2) → 3-iodo-4-phenylquinoline (809274-63-3)

Guidance literature:

With Iodine monochloride; In dichloromethane; at 20 ℃; for 2h;

Reference yield: 38.0%

N-(1-benzyl-3-phenylprop-2-ynyl)aniline (1217436-49-1) → 2-benzyl-3-iodo-4-phenylquinoline (1217436-50-4) + 3-iodo-4-phenylquinoline (809274-63-3)

Guidance literature:

With iodine; sodium hydrogencarbonate; In acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1016/j.tet.2009.12.012

upstream raw materials:

N-(3-phenylprop-2-ynyl)benzenamine

3-iodo-1-methanesulfonyl-4-phenyl-1,2-dihydroquinoline

N-phenyl-N-prop-2-ynylamine

iodobenzene

Downstream raw materials:

3,4-diphenylquinoline

4-phenylquinoline

indeno[1,2,3-de]quinoline

Refernces

• 1、 -. "Hypervalent iodine compound containing heterocyclic ring as well as preparation method and application thereof". Paragraph 0116; 0117; 0120. . Retrieved 2019/01/08.
• 2、 Sasaki, Teppei,Moriyama, Katsuhiko,Togo, Hideo. "Preparation of 3-Iodoquinolines from N-Tosyl-2-propynylamines with Diaryliodonium Triflate and N-Iodosuccinimide". . p. 11727 - 11734. Retrieved 2017/11/28.