4-BroMo-2-isopropyl aniline

Base Information

• Chemical Name: 4-BroMo-2-isopropyl aniline
• CAS No.: 81090-34-8
• Molecular Formula: C9H12BrN
• Molecular Weight: 214.105
• Mol file: 81090-34-8.mol

Synonyms:4-bromo-2-iso-propyl-phenylamine;4-Bromo-2-isopropylaniline;

Chemical Property of 4-BroMo-2-isopropyl aniline

Chemical Property:

• PSA: 26.02000
• LogP: 3.73590
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98% ^*data from raw suppliers

4-Bromo-2-isopropylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4-Bromo-2-isopropylaniline is an intermediate used to prepare oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B.

Technology Process of 4-BroMo-2-isopropyl aniline

There total 2 articles about 4-BroMo-2-isopropyl aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-isopropylaniline (643-28-7) → 4-bromo-2-isopropyl-aniline (81090-34-8)

Guidance literature:

With 1,3-di-n-butyl-1H-imidazol-3-ium tribromide; at 20 ℃; regioselective reaction; Neat (no solvent);

DOI:10.1080/00397910903009430

Reference yield: 57.0%

→ 4-bromo-2-isopropyl-aniline (81090-34-8)

Guidance literature:

Reference yield: 92.0%

2,4,7-trinitrofluorene-9-one (129-79-3) + 4-bromo-2-isopropyl-aniline (81090-34-8) → N-(2,4,7-trinitrofluorenylidene)-4-bromo-2-isopropylaniline

Guidance literature:

With zinc(II) chloride; at 150 - 170 ℃;

DOI:10.1039/JM9960601113

upstream raw materials:

2-isopropylaniline

Downstream raw materials:

methyl N-acetyl-4-amino-3-isopropylphenylalaninate

2-acetylamino-3-(4-amino-3-isopropyl-phenyl)-propionic acid

N-(4-bromo-2-isopropylphenyl)acetamide

N-(4-bromo-2-isopropylphenyl)benzimidamide

Refernces

• 1、 Chiellini, Grazia,Nesi, Giulia,Sestito, Simona,Chiarugi, Sara,Runfola, Massimiliano,Espinoza, Stefano,Sabatini, Martina,Bellusci, Lorenza,Laurino, Annunziatina,Cichero, Elena,Gainetdinov, Raul R.,Fossa, Paola,Raimondi, Laura,Zucchi, Riccardo,Rapposelli, Simona. "Hit-to-Lead Optimization of Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists with a Diphenylmethane-Scaffold: Design, Synthesis, and Biological Study". supporting information. p. 9825 - 9836. Retrieved 2016/11/19.
• 2、 Joseph, Roymon,Masson, Eric. "Subtle "supramolecular buttressing effects" in Cucurbit[7]uril/guest assemblies". . p. 3116 - 3127. Retrieved 2013/06/05.