1,2-Dibenzoyl-1-methylhydrazine

Base Information

• Chemical Name: 1,2-Dibenzoyl-1-methylhydrazine
• CAS No.: 21150-15-2
• Molecular Formula: C15H14N2O2
• Molecular Weight: 254.288
• Mol file: 21150-15-2.mol

Synonyms:N,N'-dibenzoyl-N-methyl-hydrazine;1,2-Dibenzoyl-1-methylhydrazine;Benzoic acid N'-benzoyl-N'-methyl-h;ydrazide;

Chemical Property of 1,2-Dibenzoyl-1-methylhydrazine

Chemical Property:

• Melting Point: 138-142 °C
• Boiling Point: °Cat760mmHg
• PKA: 10.98±0.46(Predicted)
• Flash Point: °C
• PSA: 49.41000
• Density: 1.194g/cm³
• LogP: 2.49450

Purity/Quality:

98% ^*data from raw suppliers

Benzoic acid N'-benzoyl-N'-methylhydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2-Dibenzoyl-1-methylhydrazine

There total 12 articles about 1,2-Dibenzoyl-1-methylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-benzoyl-2-methylhydrazine (1660-24-8) + benzoyl chloride (98-88-4) → N,N'-dibenzoyl-N-methyl-hydrazine (21150-15-2)

Guidance literature:

1-benzoyl-2-methylhydrazine; benzoyl chloride; In dichloromethane; at 0 ℃; for 0.25h;

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 0.75h;

DOI:10.1021/acs.orglett.1c00834

Reference yield: 85.0%

dimethyl acetylenedicarboxylate (762-42-5) + Trifluoro-methanesulfonate2,5-diphenyl-3-trimethylsilanylmethyl-[1,3,4]oxadiazol-3-ium; → N,N'-dibenzoyl-N-methyl-hydrazine (21150-15-2) + 1-Benzoylamino-2-phenyl-1H-pyrrole-3,4-dicarboxylic acid dimethyl ester

Guidance literature:

With cesium fluoride; In dichloromethane; at -60 ℃; for 120h;

Reference yield:

1-methyl-1-benzoylhydrazine (1483-24-5) → N,N'-dibenzoyl-N-methyl-hydrazine (21150-15-2) + methylhydrazine (60-34-4)

Guidance literature:

upstream raw materials:

1-methyl-1-benzoylhydrazine

benzoic acid anhydride

methylhydrazine

N²-Methyl-N²-thiobenzoyl-benzhydrazid

Refernces

• 1、 Butler, Richard N.,Cloonan, Martin O.. "1,3,4-Oxadiazolium-3-unsubstituted methanide 1,3-dipoles: useful synthons at -60 deg C: new synthesis of 1,2,3-trisubstituted and 1,2,3,4-tetrasubstituted pyrroles". . p. 515 - 518. Retrieved 2007/10/03.