Phosphoaminophosphonic acid-adenylate ester

Base Information

• Chemical Name: Phosphoaminophosphonic acid-adenylate ester
• CAS No.: 25612-73-1
• Molecular Formula: C₁₀H₁₇N₆O₁₂P₃
• Molecular Weight: 506.199
• DSSTox Substance ID: DTXSID90180289
• Nikkaji Number: J152.172A
• Wikidata: Q15989037
• Pharos Ligand ID: 1K4VVRCWUSNU
• Metabolomics Workbench ID: 56791
• ChEMBL ID: CHEMBL1230989
• Mol file: 25612-73-1.mol

Synonyms:Adenosine 5'-(beta,gamma-Imino)triphosphate;Adenyl Imidodiphosphate;Adenylimidodiphosphate;Adenylyl Imidodiphosphate;Adenylylimidodiphosphate;AMP-PNP;AMP-PNP, Mg;AMPPNP;ATP(beta,gamma-NH);beta,gamma imido ATP;beta,gamma-imido-ATP;gamma Imido ATP;gamma Imino ATP;gamma-Imido-ATP;gamma-Imino-ATP;Imidodiphosphate, Adenyl;Imidodiphosphate, Adenylyl;Mg 5' Adenylylimidodiphosphate;Mg AMP PNP;Mg AMP-PNP;Mg-5'-Adenylylimidodiphosphate

Chemical Property of Phosphoaminophosphonic acid-adenylate ester

Chemical Property:

• Boiling Point: 965.5°Cat760mmHg
• Flash Point: 537.7°C
• PSA: 311.36000
• Density: 2.65g/cm³
• LogP: -1.08390
• Storage Temp.: ?20°C
• Solubility.: H2O: soluble50mg/mL
• XLogP3: -6
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 17
• Rotatable Bond Count: 8
• Exact Mass: 506.01173099
• Heavy Atom Count: 31
• Complexity: 801

Purity/Quality:

98%,99%, ^*data from raw suppliers

AMPPNP ≥90%(HPLC) ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(NP(=O)(O)O)O)O)O)N
• Isomeric SMILES: C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)(NP(=O)(O)O)O)O)O)N
• Uses: AMP-PNP is a competitive inhibitor of most ATP-dependent systems. A good substrate for enzymes hydrolyzing between the α- and β-phosphorus atom, yet is resistant to enzymes cleaving between the β- and γ-phosphorus atom. Substrate of snake venom phosphodiesterase and adenylate cyclase. AMP-PNP has been used for two-motor fluorescence assay. Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate has been used in a study to research the effects of monovalent cations Li+, Na+, K+, NH4+, Rb+ and Cs+ on the solid and solution structures of the nucleic acid components. Adenosine 5′-(β,γ-imido)triphosphate lithium salt hydrate has also been used in a study to determine that antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide.

Technology Process of Phosphoaminophosphonic acid-adenylate ester

There total 1 articles about Phosphoaminophosphonic acid-adenylate ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ adenosine 5-(β,γ-imino)triphosphate (25612-73-1)

Guidance literature:

DOI:10.1021/bi00789a009