2-Azaniumylethyl hydrogen phosphate

Base Information

• Chemical Name: 2-Azaniumylethyl hydrogen phosphate
• CAS No.: 1071-23-4
• Molecular Formula: C2H8 N O4 P
• Molecular Weight: 141.064
• Hs Code.: 29221990
• Mol file: 1071-23-4.mol

Synonyms:2-azaniumylethyl hydrogen phosphate

Chemical Property of 2-Azaniumylethyl hydrogen phosphate

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 2.2E-05mmHg at 25°C
• Melting Point: 241-243 °C(lit.)
• Boiling Point: 335.8°Cat760mmHg
• PKA: pK1:5.838(+1);pK2:10.638(0) (25°C)
• Flash Point: 156.9°C
• PSA: 102.59000
• Density: 1.554g/cm³
• LogP: -0.24530
• Storage Temp.: −20°C
• Water Solubility.: Soluble in water
• XLogP3: -4.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 141.01909473
• Heavy Atom Count: 8
• Complexity: 95.9

Purity/Quality:

98% ^*data from raw suppliers

Phosphorylethanolamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T,C
• Statements: 25-34
• Safety Statements: 26-36/37/39-45-27

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(COP(=O)(O)[O-])[NH3+]
• Uses: O-PHOSPHORYLETHANOLAMINEe is used in the synthesis of Sphingomyelin, a type of sphingolipid found in animal cell membrane. O-Phosphorylethanolamine has been used:in LHC-8 medium as a supplement in culturing the transformed human liver epithelial (THLE)-2 and THLE-3 cellsin C-reactive protein (CRP) binding sucrose flotation experimentto incubate phosphomonoesters with anion-exchange chromatography (AEC) fractions for the detection of phosphatase activityto add in the washed beads for the preparation of phosphorylethanolamine (Pet) -conjugated sepharose column for chromatographic purification of mutant CRP

Technology Process of 2-Azaniumylethyl hydrogen phosphate

There total 14 articles about 2-Azaniumylethyl hydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

ethanolamine (141-43-5) → 2-aminoethyl dihydrogen phosphate (1071-23-4)

Guidance literature:

With phosphoric acid; at 100 ℃; for 3h; under 10 Torr;

DOI:10.1039/c39920000068

Reference yield:

C10H13N2O9P2(3-) → 2-aminoethyl dihydrogen phosphate (1071-23-4) + pyridoxal 5'-phosphate (54-47-7)

Guidance literature:

at 37 ℃; pH=7.4; Kinetics; Equilibrium constant; aq. phosphate buffer;

DOI:10.1016/j.bmc.2011.06.018

Reference yield:

Sphingosine-1-phosphate (26993-30-6,26993-39-5) → 2-aminoethyl dihydrogen phosphate (1071-23-4) + (E)-hexadec-2-enal (3163-37-9,51534-41-9,22644-96-8)

Guidance literature:

With pyridoxal 5'-phosphate; human sphingosine-1-phosphate lyase; In water; dimethyl sulfoxide; at 20 ℃; for 22h; pH=8; Reagent/catalyst; Kinetics; Enzymatic reaction;

DOI:10.1016/j.bmcl.2016.02.084

upstream raw materials:

ethyleneimine

dimethylenecyclourethane

2-chloroethyl phosphoric acid

(2-hydroxy-ethyl)-amidophosphoric acid diisopropyl ester

Downstream raw materials:

phosphoric acid mono-[2-(toluene-4-sulfonylamino)-ethyl ester]

2-(Dimethoxytributylamino)-ethyl-1-phosphat

2-Guanidino-aethyl-phosphat

dilithium 2-(benzyloxycarbonylamino)ethyl phosphate

Refernces

• 1、 Maheen, Gull,Tian, Ge,Wang, Yingwu,He, Chao,Shi, Zhan,Yuan, Hongming,Feng, Shouhua. "Resolving the enigma of prebiotic C-O-P bond formation: Prebiotic hydrothermal synthesis of important biological phosphate esters". . p. 161 - 167. Retrieved 2010.
• 2、 Taguchi,Mushika. "". . p. 1913,1915. Retrieved 1975.
• 3、 Grollman,Osborn. "". . p. 1571,1573,1574. Retrieved 1964.
• 4、 Patnaik, Soma,Tripathi, Sushil Kumar,Goyal, Ritu,Arora,Mitra, Kalyan,Villaverde,Vazquez,Shukla,Kumar,Gupta. "Polyethylenimine-polyethyleneglycol-bis(aminoethylphosphate) nanoparticles mediated efficient DNA and siRNA transfection in mammalian cells". experimental part. p. 6103 - 6112. Retrieved 2012/05/20.