4-(4-Fluorobenzoyl)piperidine hydrochloride

Base Information

• Chemical Name: 4-(4-Fluorobenzoyl)piperidine hydrochloride
• CAS No.: 25519-78-2
• Molecular Formula: C12H14FNO^.HCl
• Molecular Weight: 243.709
• Hs Code.: 2933399090
• European Community (EC) Number: 247-070-0
• DSSTox Substance ID: DTXSID40180219
• Mol file: 25519-78-2.mol

Synonyms:25519-78-2;4-(4-Fluorobenzoyl)piperidine hydrochloride;(4-fluorophenyl)(piperidin-4-yl)methanone hydrochloride;p-Fluorophenyl 4-piperidyl ketone hydrochloride;4-Fluorophenyl 4-piperidinyl ketone hydrochloride;4-(4-fluorobenzoyl)piperidine hcl;4-(4-Fluorobenzoyl)piperidine, HCl;EINECS 247-070-0;MFCD00044912;p-Fluorophenyl 4-piperidyl ketone HCl;(4-Fluoro-phenyl)-piperidin-4-yl-methanone hydrochloride;4-(4-fluoro-benzoyl)-piperidine hydrochloride;(4-fluorophenyl)-piperidin-4-ylmethanone;hydrochloride;Methanone, (4-fluorophenyl)-4-piperidinyl-, hydrochloride;(4-FLUOROPHENYL)(4-PIPERIDYL)METHANONE HYDROCHLORIDE;4-(4'-fluorobenzoyl)piperidine hydrochloride;C12H14FNO.ClH;SCHEMBL224933;AMY5258;DTXSID40180219;GPKDBZQZPNOBGM-UHFFFAOYSA-N;C12-H14-F-N-O.Cl-H;AKOS005063582;AC-4597;CS-W014644;LF-0526;SB36215;SY025955;4-(4-fluorbenzoyl)piperidine hydrochloride;4-(4-flurobenzoyl)piperidine hydrochloride;4-(p-fluorobenzoyl)piperidine hydrochloride;4-(4-fluorobenzoyl) piperidine.hydrochloride;4-(4-fluorobenzoyl)-piperidine hydrochloride;4-(4-Fluorobenzoyl)piperidine, hydrochloride;4-(p-fluorobenzoyl)-piperidine hydrochloride;FT-0616623;4-(4-fluorobenzoyl) piperidine. hydrochloride;EN300-30363;p-fluorophenyl 4-piperidinyl ketone hydrochloride;4-(4-fluorobenzoyl)piperidine, hydrochloride salt;A817890;J-515413;(4-fluorophenyl)(4-piperidinyl)methanone hydrochloride;(4-fluorophenyl)piperidin-4-ylmethanone hydrochloride;(4-fluorophenyl) (4-piperidinyl) methanone hydrochloride;(4-fluorophenyl) (4-piperidinyl)methanone hydrochloride;(4-fluorophenyl)(4-piperidinyl)-methanone hydrochloride;4-(4-fluorobenzoyl)piperidine hydrochloride, AldrichCPR;Z228474620;(4-fluorophenyl)-(4-piperidyl)methanone hydrochloride

Chemical Property of 4-(4-Fluorobenzoyl)piperidine hydrochloride

Chemical Property:

• Vapor Pressure: 0.000266mmHg at 25°C
• Melting Point: 222-224 °C
• Boiling Point: 323.2 °C at 760 mmHg
• Flash Point: 149.3 °C
• PSA: 29.10000
• Density: 0.99g/cm3
• LogP: 3.13880
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Hygroscopic
• Solubility.: DMSO (Slightly), Water (Slightly)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 243.0826200
• Heavy Atom Count: 16
• Complexity: 218

Purity/Quality:

99.9% ^*data from raw suppliers

4-(4-Fluorobenzoyl)piperidinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi, C
• Hazard Codes: Xi,C,Xn
• Statements: 36/37/38-20/21/22-22
• Safety Statements: 26-36/37/39-22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1C(=O)C2=CC=C(C=C2)F.Cl
• Uses: 4-(4-Fluorobenzoyl)piperidine hydrochloride is a piperidnyl derivative used in the preparation of antiarrhythmics as well as α1-adrenoceptor and S2-receptor antagonists for circulatory diseases. 4-(4-Fluorobenzoyl)piperidine, HCl

Technology Process of 4-(4-Fluorobenzoyl)piperidine hydrochloride

There total 4 articles about 4-(4-Fluorobenzoyl)piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-(4-fluorobenzoyl)piperidin-1-yl)ethanone (25519-77-1) → 4-(4-fluorobenzoyl)piperidine hydrochloride (25519-78-2)

Guidance literature:

In hydrogenchloride;

Reference yield:

tert-butyl 1-[4-(4-fluorobenzoyl)piperidin-1-yl]carboxylate (160296-40-2) → 4-(4-fluorobenzoyl)piperidine hydrochloride (25519-78-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1016/j.bmcl.2009.10.101

Reference yield:

1-acetylpiperidine-4-carbonyl chloride (59084-16-1) → 4-(4-fluorobenzoyl)piperidine hydrochloride (25519-78-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminium trichloride / fluorobenzene

2: hydrogenchloride

aluminium trichloride; In hydrogenchloride; fluorobenzene;

upstream raw materials:

1-(4-(4-fluorobenzoyl)piperidin-1-yl)ethanone

tert-butyl 1-[4-(4-fluorobenzoyl)piperidin-1-yl]carboxylate

1-acetylpiperidine-4-carbonyl chloride

Downstream raw materials:

1-{4-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-butyl}-7-methyl-6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione 4-(O-methyl-oxime)

(E)-1-<4-<4-(4-fluorobenzoyl)piperidino>butyl>-4-hydroxyimino-7-methyl-1,4,5,6,7,8-hexahydropyrrolo<2,3-c>azepin-8-one

Refernces

• 1、 -. "7-fused 2-(piperazinoalkyl) indole derivatives, intermediates and compositions thereof". . . Retrieved 2008/06/13.
• 2、 -. "1,5-Disubstituted-1,2-dihydro-2H-1,4-benzodiazepin-2-ones". . . Retrieved 2008/06/13.