(E)-3-(3,4-DIMETHOXYPHENYL)-1-(3-HYDROXYPHENYL)-1-PROPENONE

Base Information

• Chemical Name: (E)-3-(3,4-DIMETHOXYPHENYL)-1-(3-HYDROXYPHENYL)-1-PROPENONE
• CAS No.: 178445-80-2
• Molecular Formula: C17H16 O4
• Molecular Weight: 284.312
• Hs Code.: 2914509090
• Mol file: 178445-80-2.mol

Synonyms:(E)-3,4-Dimethoxy-3'-hydroxychalcone;(E)-3-(3,4-Dimethoxyphenyl)-1-(3-hydroxyphenyl)-2-propen-1-one

Chemical Property of (E)-3-(3,4-DIMETHOXYPHENYL)-1-(3-HYDROXYPHENYL)-1-PROPENONE

Chemical Property:

• Vapor Pressure: 3.74E-10mmHg at 25°C
• Boiling Point: 488.2°Cat760mmHg
• Flash Point: 180.7°C
• PSA: 55.76000
• Density: 1.203g/cm³
• LogP: 3.30550

Purity/Quality:

98% ^*data from raw suppliers

(E)-3,4-Dimethoxy-3-hydroxychalcone 95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (E)-3-(3,4-DIMETHOXYPHENYL)-1-(3-HYDROXYPHENYL)-1-PROPENONE

There total 3 articles about (E)-3-(3,4-DIMETHOXYPHENYL)-1-(3-HYDROXYPHENYL)-1-PROPENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-Hydroxyacetophenone (121-71-1) + 3,4-dimethoxy-benzaldehyde (120-14-9) → (E)-1-(3,4-dimethoxyphenyl)-3-(3-hydroxyphenyl)prop-2-en-1-one (178445-80-2)

Guidance literature:

With potassium hydroxide; In ethanol; at 0 - 20 ℃; for 16h;

DOI:10.1021/acscombsci.9b00197

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) → (E)-1-(3,4-dimethoxyphenyl)-3-(3-hydroxyphenyl)prop-2-en-1-one (178445-80-2)

Guidance literature:

With hydrogenchloride; aqueous KOH; In ethanol;

Reference yield:

→ (E)-1-(3,4-dimethoxyphenyl)-3-(3-hydroxyphenyl)prop-2-en-1-one (178445-80-2)

Guidance literature:

upstream raw materials:

3-Hydroxyacetophenone

3,4-dimethoxy-benzaldehyde

Downstream raw materials:

3-(3,4-dimethoxyphenyl)-1-(3-hydroxyphenyl)-1-propanone

2-{3-[(1R)-3-(3,4-dimethoxyphenyl)-1-hydroxypropyl]phenoxy}acetic acid

2[[3-(3,4-dimethyoxyphenyl)-1-oxopropyl]phenoxy]acetic acid 1,1-dimethylester

(R)-1-(3-(tert-butoxycarbonylmethoxy)phenyl)-3-(3,4-dimethoxyphenyl)-propan-1-ol

Refernces

• 1、 Bols, Mikael,Diness, Frederik,J?rgensen, Frederik P.,Madsen, Daniel,Meldal, Morten,Olsen, Jakob V.,Palmer, Daniel,Roux, Milena E.,Schoffelen, Sanne. "Design and Combinatorial Development of Shield-1 Peptide Mimetics Binding to Destabilized FKBP12". supporting information. . Retrieved 2020/03/10.
• 2、 Cong, Lin,Dong, Xiyu,Wang, Yan,Deng, Yulin,Li, Bo,Dai, Rongji. "On the role of synthesized hydroxylated chalcones as dual functional amyloid-β aggregation and ferroptosis inhibitors for potential treatment of Alzheimer's disease". . p. 11 - 21. Retrieved 2019/01/26.