Dalbavancin

Base Information

• Chemical Name: Dalbavancin
• CAS No.: 171500-79-1
• Molecular Formula: C88H100 Cl2 N10 O28
• Molecular Weight: 1816.71
• Mol file: 171500-79-1.mol

Synonyms:A-A1;BI 397;Dalbavancin;Dalbavancin B0;MDL 63397;VER 001;Ristomycin A aglycone,5,31-dichloro-38-de(methoxycarbonyl)-7-demethyl-19-deoxy-56-O-[2-deoxy-2-[(10-methyl-1-oxoundecyl)amino]-b-D-glucopyranuronosyl]-38-[[[3-(dimethylamino)propyl]amino]carbonyl]-42-O-a-D-mannopyranosyl-N15-methyl-;

Chemical Property of Dalbavancin

Chemical Property:

• PKA: 2.73±0.70(Predicted)
• PSA: 572.51000
• Density: 1.59
• LogP: 7.31350
• Storage Temp.: -20°C
• Solubility.: Aqueous Base (Slightly), DMSO (Slightly, Heated), Water (Slightly)

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

Dalbavancin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• description: Dalbavancin is a second generation, semi-synthetic lipoglycopeptide antibiotic that is active against gram-positive pathogens with a MIC90for Staphylococcus aureus of 0.06 μg/mL. Dalbavancin possesses more potent in vitro bactericidal activity than vancomycin or teicoplanin against many resistant Gram-positive organisms such as MRSA. Dalbavanacin displays prolonged terminal half-life in adults.Compared to existing glycopeptides anti-MRSA(Methicillin-Resistant Staphylococcus Aureus) antibiotics, it has better antibiotic strength and, because it only needs to be taken once a week, it will be easier for both patients and medical care providers. It also offers stable absorption and metabolism for patients with light to moderate kidney and liver dysfunction. We know that its interactions with other medications are extremely small, and it is proving to be very safe in clinical trials. Dalbavancin is specifically indicated for the treatment of adult patients with acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible isolates of the following Gram-positive microorganisms: Staphylococcus aureus (including methicillin-susceptible and methicillin-resistant strains), Streptococcus pyogenes, Streptococcus agalactiae and Streptococcus anginosus group (including S. anginosus, S. intermedius, S. constellatus). Class??? Glycopeptide anti-MRSA antibiotic Mechanism of Action??? Cell Wall Peptidoglycan Synthesis Inhibitor Target Indication??? MRSA Infections
• Uses: Dalbavancin is a semi-synthetic glycopeptide prepared from A40926 by introducing a positively charged lipophilic moiety in a previously unexplored region of the natural glycopeptide. This modification provides a longer in vivo half life, and improved in vitro activity against a variety of Gram positive and multi-drug resistant isolates such as MRSA and MRSE. Dalbavancin is a second-generation lipoglycopeptide antibiotic. It is a semisynthetic lipoglycopeptide that was designed to improve upon the natural glycopeptides currently available, vancomycin and teicoplanin.