6β,17α-Dihydroxyprogesterone

Base Information

• Chemical Name: 6β,17α-Dihydroxyprogesterone
• CAS No.: 604-03-5
• Molecular Formula: C21H30O4
• Molecular Weight: 346.467
• Mol file: 604-03-5.mol

Synonyms:

Chemical Property of 6β,17α-Dihydroxyprogesterone

Chemical Property:

• Vapor Pressure: 2.52E-13mmHg at 25°C
• Melting Point: >216°C (dec.)
• Boiling Point: 527.4°Cat760mmHg
• Flash Point: 286.8°C
• Density: 1.21g/cm³
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), DMSO (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

6β,17α-Dihydroxyprogesterone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6β,17α-Dihydroxyprogesterone is a derivative of Progesterone (P755900) which is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.

Technology Process of 6β,17α-Dihydroxyprogesterone

There total 16 articles about 6β,17α-Dihydroxyprogesterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Progesterone (57-83-0) → testosterone acetate (1045-69-8) + 6β,11α-dihydroxyprogesterone (600-48-6) + 12β,17α-dihydroxyprogesterone (604-03-5) + 6β,11α,20(R)-trihydroxypregna-4-en-3-one

Guidance literature:

With Cephalosporium aphidicola; In ethanol; for 168h;

DOI:10.1016/S0031-9422(00)90346-7

Reference yield:

3,20-diacetoxy-pregna-3,5,20-triene (64026-12-6) → 12β,17α-dihydroxyprogesterone (604-03-5)

Guidance literature:

With Perbenzoic acid;

Reference yield:

Progesterone (57-83-0) → 12β,17α-dihydroxyprogesterone (604-03-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Cephalosporium aphidicola / ethanol / 72 h

2: 227 mg / Cephalosporium aphidicola / ethanol / 168 h

With Cephalosporium aphidicola; In ethanol;

DOI:10.1016/S0031-9422(00)90346-7

upstream raw materials:

17-hydroxyprogesterone

6β-acetoxy-17-hydroxy-pregn-4-ene-3,20-dione

3β,6β,17-trihydroxy-pregn-4-en-20-one

3,20-diacetoxy-pregna-3,5,20-triene

Refernces