Heptanamide, 6-oxo-N-[4-(trifluoromethyl)phenyl]-

Base Information

• Chemical Name: Heptanamide, 6-oxo-N-[4-(trifluoromethyl)phenyl]-
• CAS No.: 84417-40-3
• Molecular Formula: C14H16F3NO2
• Molecular Weight: 287.282
• Mol file: 84417-40-3.mol

Synonyms:

Chemical Property of Heptanamide, 6-oxo-N-[4-(trifluoromethyl)phenyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Heptanamide, 6-oxo-N-[4-(trifluoromethyl)phenyl]-

There total 3 articles about Heptanamide, 6-oxo-N-[4-(trifluoromethyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

6-oxoheptanoic acid (3128-07-2) + 4-trifluoromethylphenylamine (455-14-1) → 6-oxo-N-<4-(trifluoromethyl)phenyl>heptanamide (84417-40-3)

Guidance literature:

With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran;

DOI:10.1021/jm00163a036

Reference yield: 78.4%

4-trifluoromethylphenylamine (455-14-1) + 6-oxoheptanoic acid chloride (56721-54-1) → 6-oxo-N-<4-(trifluoromethyl)phenyl>heptanamide (84417-40-3)

Guidance literature:

With dmap; triethylamine; In N,N-dimethyl-formamide; for 1.5h; Ambient temperature;

DOI:10.1002/hlca.19880710204

Reference yield:

6-oxoheptanoic acid (3128-07-2) → 6-oxo-N-<4-(trifluoromethyl)phenyl>heptanamide (84417-40-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 79.7 percent / benzene / 1 h / 50 °C

2: 78.4 percent / 4-(dimethylamino)pyridine, Et₃N / dimethylformamide / 1.5 h / Ambient temperature

With dmap; triethylamine; In N,N-dimethyl-formamide; benzene;

DOI:10.1002/hlca.19880710204

upstream raw materials:

6-oxoheptanoic acid

4-trifluoromethylphenylamine

6-oxoheptanoic acid chloride

Downstream raw materials:

6-[(E)-(R)-2-(3,4-Dihydroxy-phenyl)-2-hydroxy-ethylimino]-heptanoic acid (4-trifluoromethyl-phenyl)-amide

6-[2-(4-imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)heptanecarboxamide

(S)-6-Amino-heptanoic acid (4-trifluoromethyl-phenyl)-amide; compound with methanesulfonic acid

(R)-6-Amino-heptanoic acid (4-trifluoromethyl-phenyl)-amide; compound with methanesulfonic acid

Refernces

• 1、 Marki,Crameri,Eigenmann,Krasso,Ramuz,Bernauer,Goodman,Melmon. "Optically pure isoproterenol analogues with side chains containing an amide bond: Synthesis and biological properties". . p. 320 - 336. Retrieved 2007/10/02.