2-(2-Methylphenoxy)ethanol

Base Information

• Chemical Name: 2-(2-Methylphenoxy)ethanol
• CAS No.: 6161-86-0
• Molecular Formula: C9H12O2
• Molecular Weight: 152.193
• NSC Number: 24016
• UNII: FNA5XUK0A2
• DSSTox Substance ID: DTXSID90210631
• Nikkaji Number: J49.847E
• Wikidata: Q83085384
• Mol file: 6161-86-0.mol

Synonyms:2-(2-Methylphenoxy)ethanol;6161-86-0;2-(o-Tolyloxy)ethanol;2-o-Cresoxyethanol;Phenoxyethanol, o-methyl-;Ethanol, 2-(2-methylphenoxy)-;ETHANOL, 2-(o-TOLYLOXY)-;Ether, 2-(hydroxyethyl) o-tolyl;Ethyl alcohol, 2-(o-tolyloxy)-;o-Tolyloxyethanol;beta-Hydroxyethyl ether of o-cresol;NSC 24016;FNA5XUK0A2;BRN 2045335;AI3-09179;2-(2-methyl-phenoxy)-ethanol;NSC-24016;4-06-00-01947 (Beilstein Handbook Reference);2-(Methylphenoxy)ethanol;UNII-FNA5XUK0A2;ethylene glycol tolyl ether;o-(2-hydroxyethoxy)toluene;WLN: Q2OR B1;SCHEMBL515977;DTXSID90210631;.BETA.-(O-TOLYLOXY)ETHANOL;NSC24016;.BETA.-(O-CRESYLOXY)ETHANOL;.beta.-Hydroxyethyl ether of o-cresol;AKOS000296348;LS-67070;E97734

Chemical Property of 2-(2-Methylphenoxy)ethanol

Chemical Property:

• Vapor Pressure: 0.0086mmHg at 25°C
• Boiling Point: 255.1°Cat760mmHg
• Flash Point: 108.5°C
• PSA: 29.46000
• Density: 1.058g/cm³
• LogP: 1.36610
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 152.083729621
• Heavy Atom Count: 11
• Complexity: 104

Purity/Quality:

99% ^*data from raw suppliers

2-(2-METHYLPHENOXY)ETHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1OCCO

Technology Process of 2-(2-Methylphenoxy)ethanol

There total 10 articles about 2-(2-Methylphenoxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-methylphenyl bromide (95-46-5) + ethylene glycol (107-21-1) → 2-methylphenoxyethanol (6161-86-0)

Guidance literature:

With potassium carbonate; copper dichloride; at 130 ℃; for 20h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c4ob00649f

Reference yield: 89.0%

o-methylphenoxyacetic acid (1878-49-5) → 2-methylphenoxyethanol (6161-86-0)

Guidance literature:

Reference yield: 78.6%

→ 2-methylphenoxyethanol (6161-86-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 4h;

upstream raw materials:

oxirane

ethanol

sodium ethanolate

ortho-cresol

Downstream raw materials:

β-o-Tolyloxyphenyl-m-tolylcarbamat

7-chloro-5-[(4-methyl-1-piperazinyl)carbonyl-methyl]-1-[2-methoxy-4-{N-[2-(2-methylphenoxy)ethyl]-N-trifluoroacetylamino}-benzoyl]-2,3,4,5-tetrahydro-1H-benzazepine

(2-methylphenoxy)acetaldehyde

7-methylbenzofuran

Refernces

• 1、 -. "Formononetin derivatives and preparation methods and medical application thereof". Paragraph 0123; 0124; 0125; 0129; 0130; 0131. . Retrieved 2017/04/29.
• 2、 Elhalem, Eleonora,Bailey, Brian N.,Docampo, Roberto,Ujváry, István,Szajnman, Sergio H.,Rodriguez, Juan B.. "Design, synthesis, and biological evaluation of aryloxyethyl thiocyanate derivatives against Trypanosoma cruzi". . p. 3984 - 3999. Retrieved 2007/10/03.