2-Chloro-1,1-diethoxyethane

Base Information

• Chemical Name: 2-Chloro-1,1-diethoxyethane
• CAS No.: 621-62-5
• Molecular Formula: C6H13ClO2
• Molecular Weight: 152.621
• Hs Code.: 29110000
• European Community (EC) Number: 210-695-4
• NSC Number: 8436
• UNII: 2V59K8R7DE
• DSSTox Substance ID: DTXSID4060735
• Nikkaji Number: J6.833K
• Wikidata: Q72516842
• ChEMBL ID: CHEMBL2251332
• Mol file: 621-62-5.mol

Synonyms:2-chloroacetal

Chemical Property of 2-Chloro-1,1-diethoxyethane

Chemical Property:

• Appearance/Colour: Clear, colorless liquid.
• Vapor Pressure: <0.02 atm ( 20 °C)
• Melting Point: -45 °C
• Refractive Index: n20/D 1.416(lit.)
• Boiling Point: 157.4 °C at 760 mmHg
• Flash Point: 29.4 °C
• PSA: 18.46000
• Density: 1.018g/cm³
• LogP: 1.62430
• Storage Temp.: Flammables area
• Sensitive.: Moisture Sensitive
• Solubility.: 1.8g/l
• Water Solubility.: 1.8 g/L (20 ºC)
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 152.0604073
• Heavy Atom Count: 9
• Complexity: 53

Purity/Quality:

99% ^*data from raw suppliers

Chloroacetaldehyde Diethyl Acetal ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi; Xn
• Hazard Codes: Xn,Xi
• Statements: 10-22-36/37/38
• Safety Statements: 28A-26-16-36-23-7/9

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Acetals
• Canonical SMILES: CCOC(CCl)OCC

Technology Process of 2-Chloro-1,1-diethoxyethane

There total 26 articles about 2-Chloro-1,1-diethoxyethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.7%

ethanol (64-17-5) + 1,2-dichloro-2-ethoxyethane (623-46-1) → chloroacetaldehyde diethyl acetal (621-62-5)

Guidance literature:

With sodium ethanolate; at 20 ℃; for 1h; Cooling with ice; Green chemistry;

Reference yield: 93.0%

2-chloroethanal (107-20-0) + ethanol (64-17-5) → chloroacetaldehyde diethyl acetal (621-62-5)

Guidance literature:

With toluene-4-sulfonic acid; In chloroform; Reflux; Large scale;

Reference yield: 64.0%

vinyl acetate (108-05-4,9003-20-7) + ethanol (64-17-5) → chloroacetaldehyde diethyl acetal (621-62-5)

Guidance literature:

With chlorine; at 1 - 4 ℃; for 2h;

upstream raw materials:

2-chloroethanal

ethanol

diethyl acetal

1,2-dichloroethyl acetate

Downstream raw materials:

1-(2,2-diethoxy-ethyl)-pyrrolidine

2,4,6-tris(chloromethyl)-1,3,5-trioxane

2-chloroethanal

oxalic acid diethyl ester

Refernces

• 1、 -. "PROCESS FOR PREPARING CHLOROACETALDEHYDE ACETALS". Paragraph 0032; 0033. . Retrieved 2016/10/11.
• 2、 -. "Process for the preparation of vitamin A and intermediate compounds which are useful for this process". . . Retrieved 2008/06/13.