Sch 37370

Base Information

• Chemical Name: Sch 37370
• CAS No.: 117796-52-8
• Molecular Formula: C21H21 Cl N2 O
• Molecular Weight: 352.8572
• Mol file: 117796-52-8.mol

Synonyms:Piperidine,1-acetyl-4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-(9CI); 11H-Benzo[5,6]cyclohepta[1,2-b]pyridine, piperidine deriv.;N-Acetyldesloratadine; Sch 37370

Chemical Property of Sch 37370

Chemical Property:

• Vapor Pressure: 5.15E-12mmHg at 25°C
• Melting Point: 155-157 °C
• Boiling Point: 546.9°Cat760mmHg
• PKA: 4.16±0.20(Predicted)
• Flash Point: 284.5°C
• PSA: 33.20000
• Density: 1.257g/cm³
• LogP: 4.21570
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

N-Acetyldesloratadine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Acetyldesloratadine is an impurity in the synthesis of Desloratadine (D290250), Nonsedating-type histamine H1-receptor antagonist.

Technology Process of Sch 37370

There total 10 articles about Sch 37370 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

acetic anhydride (108-24-7) + descarboethoxyloratadine (100643-71-8) → N-acetyl desloratadine (117796-52-8)

Guidance literature:

With acetic acid; at 20 ℃; for 2h;

DOI:10.1021/op8001036

Reference yield: 70.0%

→ N-acetyl desloratadine (117796-52-8)

Guidance literature:

Reference yield:

descarboethoxyloratadine (100643-71-8) + acetyl chloride (75-36-5) → N-acetyl desloratadine (117796-52-8)

Guidance literature:

With pyridine; In dichloromethane;

DOI:10.1021/jm00105a069

upstream raw materials:

descarboethoxyloratadine

acetyl chloride

N-tert-butyl-3-methylpyridine-2-carboxamide

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile

Refernces

• 1、 Mu, Shuai,Xie, Xiao-Shuai,Niu, Duan,Zhang, Da-Shuai,Liu, Deng-Ke,Liu, Chang-Xiao. "Synthesis and biological evaluation of novel derivatives of desloratadine". . p. 531 - 534. Retrieved 2013/07/27.
• 2、 -. "Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies.". . . Retrieved 2008/06/13.