EFONIDIPINE

Base Information

• Chemical Name: EFONIDIPINE
• CAS No.: 111011-76-8
• Molecular Formula: C36H45ClN3O8P
• Molecular Weight: 714.1846
• Mol file: 111011-76-8.mol

Synonyms:Ethanol, compd. with 2-(phenyl(phenylmethyl)amino)ethyl 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate monohydrochloride;NZ 105 ethanolate;Efonidipine hydrochloride (JAN);Landel;3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-(5,5-dimethyl-1,3,2-dioxaphosphorinan-2-yl)-4-(3-nitrophenyl)-, 2-(phenyl(phenylmethyl)amino)ethyl ester, P-oxide, monohydrochloride;Efonidipine.HCl ethanolate;2-(benzyl-phenyl-amino)ethyl 5-(5,5-dimethyl-2-oxo-1,3-dioxa-2$l^C₃₆H₄₅ClN₃O₈P-phosphacyclohex-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate; ethanol; hydrochloride;Efonidipine hydrochloride;Efonidipine hydrochloride ethanol;3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-2-oxido-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(phenyl(phenylmethyl)amino)ethyl ester, monohydrochloride, compd. with ethanol (1;1);Landel (TN);

Chemical Property of EFONIDIPINE

Chemical Property:

• Vapor Pressure: 3.5E-22mmHg at 25°C
• Melting Point: 151° (dec)
• Boiling Point: 746.9 °C at 760 mmHg
• Flash Point: 405.5 °C
• PSA: 152.96000
• Density: 1.3 g/cm³
• LogP: 8.95580
• Storage Temp.: Desiccate at +4°C

Purity/Quality:

99%, ^*data from raw suppliers

Efonidipine hydrochloride monoethanolate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Efonidipine hydrochloride ethanol was first launched in Japan for the treatment of essential severe and renal hypertension. As the fourteenth dihydropyridine (DHP) calcium channel blocker to reach the market, it functions by binding to the DHP receptors on voltage-dependent calcium channels to cause diuretic and natriuretic actions in patients with essential hypertension. Its vasodilating and calcium antagonist effects are very slow in onset and long-lasting in all types of experimentally hypertensive models and the agent is reported to exhibit an improved side effect profile compared with other drugs of the same class. This may be explained by the slow and long-lasting inhibition of transmembrane Ca+2 uptake, which is accompanied by its very slow binding to and dissociation from the DHP receptors. A recent study in cholesterol-fed rabbits suggested that efonidipine may suppress the development of atherosclerosis without affecting the plasma lipids. Clinical trials for angina, peetoris, and for cerebrovasodilatory disorders have been reported.
• Uses: Efonidipine Hydrochloride Monoethanolate is a potent inhibitor of the L-type calcium channel.