(4-Methoxyphenyl)diphenylmethanol

Base Information

• Chemical Name: (4-Methoxyphenyl)diphenylmethanol
• CAS No.: 847-83-6
• Molecular Formula: C20H18 O2
• Molecular Weight: 290.362
• Hs Code.: 2909499000
• European Community (EC) Number: 212-693-9
• NSC Number: 405054
• UNII: D117S0GBOT
• DSSTox Substance ID: DTXSID00233710
• Nikkaji Number: J195.122J
• Wikidata: Q27275955
• Mol file: 847-83-6.mol

Synonyms:(4-methoxyphenyl) diphenylmethanol;(p-methoxyphenyl) diphenylmethanol

Chemical Property of (4-Methoxyphenyl)diphenylmethanol

Chemical Property:

• Vapor Pressure: 5.75E-09mmHg at 25°C
• Melting Point: 82 °C
• Boiling Point: 452.2°C at 760 mmHg
• PKA: 12.80±0.29(Predicted)
• Flash Point: 204.7°C
• PSA: 29.46000
• Density: 1.141g/cm³
• LogP: 3.97940
• Storage Temp.: 2-8°C
• Water Solubility.: Insoluble in water.
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 290.130679813
• Heavy Atom Count: 22
• Complexity: 303

Purity/Quality:

98% ^*data from raw suppliers

(4-Methoxyphenyl)diphenylmethanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)O
• Uses: It is used as an intermediate for preparation of TT-0011.

Technology Process of (4-Methoxyphenyl)diphenylmethanol

There total 41 articles about (4-Methoxyphenyl)diphenylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-Methoxybenzophenone (611-94-9) + bromobenzene (108-86-1,52753-63-6) → p-methoxytrityl alcohol (847-83-6)

Guidance literature:

bromobenzene; With magnesium; In tetrahydrofuran;

4-Methoxybenzophenone; In tetrahydrofuran; for 18h; Heating;

DOI:10.1002/ejoc.200400754

Reference yield: 80.0%

1-bromo-4-methoxy-benzene (104-92-7) + benzophenone (119-61-9) → p-methoxytrityl alcohol (847-83-6)

Guidance literature:

1-bromo-4-methoxy-benzene; With tetrahydrofuran; n-butyllithium; In cyclohexane; at 12 ℃; Inert atmosphere;

benzophenone; With water; In cyclohexane; at 12 ℃;

DOI:10.1055/s-0031-1290810

Reference yield: 80.0%

methyl 4-methoxybenzoate (121-98-2) + phenyllithium (591-51-5) → p-methoxytrityl alcohol (847-83-6)

Guidance literature:

In water; at 25 ℃; for 0.00555556h; Solvent;

DOI:10.1016/j.tet.2020.131898

upstream raw materials:

4-Methoxybenzophenone

1-bromo-4-methoxy-benzene

benzophenone

4-chloromethoxybenzene

Downstream raw materials:

(4-methoxy-trityl)-phenyl-diazene

p-Methoxyphenyl-diphenylmethyliumion

1-(4-methoxyphenyl)diphenylmethane

4-monomethoxytriphenylmethanethiol

Refernces

• 1、 Patterson, Iain L. J.,Glidewell, Christopher,Ferguson, George. "(4-Methoxyphenyl)diphenylmethanol, an unusual tetramer containing a D[R] pattern of hydrogen bonds, and tris(2-methoxyphenyl)methanol". . p. 1970 - 1974. Retrieved 1998.
• 2、 Sai, Masahiro. "An Efficient Ga(OTf)3/Isopropanol Catalytic System for Direct Reduction of Benzylic Alcohols". supporting information. p. 4330 - 4335. Retrieved 2018/10/15.
• 3、 N?sel, Pascal,Moghimi, Setareh,Hendrich, Christoph,Haupt, Marten,Rudolph, Matthias,Rominger, Frank,Hashmia, A. Stephen K.. "Oxidative gold catalysis meets photochemistry - Synthesis of benzo[a]fluorenones from diynes". supporting information. p. 3755 - 3760. Retrieved 2015/01/09.