Lobeline, (+)-

Base Information Edit

Chemical Name:Lobeline, (+)-
CAS No.:90-69-7
Molecular Formula:C22H27 N O2
Molecular Weight:337.462
Hs Code.:
European Community (EC) Number:202-012-3
UNII:74SSN124VK,73BJ3LA259
Wikipedia:Lobeline
NCI Thesaurus Code:C93261
Mol file:90-69-7.mol

Synonyms:Lobeline;Lobeline Sulfate;Smokeless;Sulfate, Lobeline

Suppliers and Price of Lobeline, (+)-

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Arctom
Lobelin ≥98%
5mg
$ 463.00

American Custom Chemicals Corporation
LOBELINE 95.00%
5G
$ 911.99

American Custom Chemicals Corporation
LOBELINE 95.00%
1G
$ 630.63

Total 51 raw suppliers

Chemical Property of Lobeline, (+)- Edit

Chemical Property:

Vapor Pressure:3.05E-10mmHg at 25°C
Melting Point:130-131°
Refractive Index:1.5614 (estimate)
Boiling Point:485.6oC at 760 mmHg
PKA:14.34±0.20(Predicted)
Flash Point:247.5oC
PSA：40.54000
Density:1.085g/cm3
LogP:4.17390
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:337.204179104
Heavy Atom Count:25
Complexity:412

Purity/Quality:

99% ^*data from raw suppliers

Lobelin ≥98% ^*data from reagent suppliers

Safty Information:

Pictogram(s): T
Hazard Codes:T
Statements: 23/24/25
Safety Statements: 36/37/39-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C(CCCC1CC(=O)C2=CC=CC=C2)CC(C3=CC=CC=C3)O
Isomeric SMILES:CN1[C@H](CCC[C@H]1CC(=O)C2=CC=CC=C2)C[C@H](C3=CC=CC=C3)O
Recent ClinicalTrials:To Assess the Safety and Tolerability of 7.5, 15 and 30 mg of Sublingual Lobeline. - 1
Description Lobeline is mainly present in Lobelia chinensis, Lobelia inflata, Campanula medium, Lobelia hassleri, and Lobelia nicotianaefolia . Lobelia inflata has also been considered as an Indian tobacco and has been used for the treatment of respiratory diseases for a long history. It was also a treatment of asthma by American Aborigines. In the United States during the nineteenth century, doctors use Lobelia inflata as a vomiting agent, to remove the poison from the body. It is also called “vomit grass.” Now Lobelia inflata is still used to clear throat, bronchial, lung, and other respiratory mucus .
Physical properties Appearance: White crystalline or granular powder, odorless, and bitter. Solubility: Soluble in ethanol or chloroform, slightly soluble in water. Melting point: 130–131?°C.
Uses Lobeline is the principal lobelia alkaloid.It occurs in the seeds and herb of Indiantobacco (Lobelia inflata and Lobeliaceae). Itis used as a respiratory stimulant. Its sulfatesalt is used in antismoking tablets.
Indications Lobeline was recorded in chemical drug and preparations as lobeline hydrochloride, which is prepared as injection for the treatment of central respiratory inhibition induced by a variety of reasons. In addition, it is also used for the treatment of neonatal stasis, carbon monoxide, opioid poisoning, and so on.
Clinical Use It is mainly used in the treatment of (1) neonatal asphyxia, (2) suffocation caused by carbon monoxide, (3) poisoning induced by inhalation of anesthetics and other central inhibitors (such as opioids and barbiturates), and (4) respiratory failure caused by pneumonia, diphtheria, and other infectious diseases.

Technology Process of Lobeline, (+)-

There total 49 articles about Lobeline, (+)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%