4'-Hydroxy-m-phenoxy benzoic acid

Base Information

• Chemical Name: 4'-Hydroxy-m-phenoxy benzoic acid
• CAS No.: 35065-12-4
• Molecular Formula: C13H10 O4
• Molecular Weight: 230.2161
• Hs Code.: 2918990090
• Mol file: 35065-12-4.mol

Synonyms:3-(4-Hydroxyphenoxy)benzoicacid; 3-(4'-Hydroxy)phenoxybenzoic acid

Chemical Property of 4'-Hydroxy-m-phenoxy benzoic acid

Chemical Property:

• Vapor Pressure: 2.04E-08mmHg at 25°C
• Melting Point: 156-157.5 °C
• Boiling Point: 437.2°C at 760 mmHg
• PKA: 4.00±0.10(Predicted)
• Flash Point: 172.7°C
• PSA: 66.76000
• Density: 1.346g/cm³
• LogP: 2.88270

Purity/Quality:

99%, ^*data from raw suppliers

3-(4''-Hydroxy)phenoxybenzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of pyrethroid insecticides such as: Deltamethrin,

Technology Process of 4'-Hydroxy-m-phenoxy benzoic acid

There total 5 articles about 4'-Hydroxy-m-phenoxy benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

3-(4-methoxyphenoxy)benzoic acid (117423-75-3) → 3-(4-hydroxyphenoxy)benzoic acid (35065-12-4)

Guidance literature:

With hydrogen bromide; acetic acid; for 48h; Heating;

DOI:10.1021/jm00172a019

Reference yield:

3-(4-methoxyphenoxy)benzaldehyde (62373-80-2) → 3-(4-hydroxyphenoxy)benzoic acid (35065-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / AgO, NaOH / H₂O / 1 h / 65 °C

2: 57 percent / 48percent HBr, acetic acid / 48 h / Heating

With silver(II) oxide; sodium hydroxide; hydrogen bromide; acetic acid; In water;

DOI:10.1021/jm00172a019

Reference yield:

1-(4-methoxyphenoxy)-3-methylbenzene (82721-04-8) → 3-(4-hydroxyphenoxy)benzoic acid (35065-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: KMnO₄

2: aqueous HI; acetic acid; acetic acid anhydride

With potassium permanganate; hydrogen iodide; acetic anhydride; acetic acid;

DOI:10.1021/jo50002a021

upstream raw materials:

3-(4-methoxyphenoxy)benzoic acid

3-(4-methoxyphenoxy)benzaldehyde

1-(4-methoxyphenoxy)-3-methylbenzene

potassium p-methoxyphenolate

Downstream raw materials:

3-(4-hydroxyphenoxy)benzoic acid, ethyl ester

5-<3-(ethoxycarbonyl)phenoxy>-2-(decyloxy)benzenepropanoic acid

5-(3-Carboxyphenoxy)-2-(decyloxy)benzenepropanoic acid

ethyl 3-<4-(decyloxy)-3-(3-hydroxypropyl)phenoxy>benzoate

Refernces

• 1、 Gapinski, D. Mark,Mallett, Barbara E.,Froelich, Larry L.,Jackson, William T.. "Benzophenone Dicarboxylic Acid Antagonists of Leukotriene B4. 1. Structure-Activity Relationships of the Benzophenone Nucleus". . p. 2798 - 2807. Retrieved 2007/10/02.