2-Bromo-4'-phenylacetophenone

Base Information

• Chemical Name: 2-Bromo-4'-phenylacetophenone
• CAS No.: 135-73-9
• Deprecated CAS: 51672-88-9
• Molecular Formula: C14H11BrO
• Molecular Weight: 275.145
• Hs Code.: 29147000
• European Community (EC) Number: 205-217-6
• NSC Number: 37117
• UNII: XRZ97JC5PS
• DSSTox Substance ID: DTXSID5059660
• Nikkaji Number: J5.615D
• Wikidata: Q81988909
• ChEMBL ID: CHEMBL413032
• Mol file: 135-73-9.mol

Synonyms:2-bromo-4'-phenylacetophenone;4-phenylphenacyl bromide

Chemical Property of 2-Bromo-4'-phenylacetophenone

Chemical Property:

• Appearance/Colour: yellowish to beige-brown powder
• Vapor Pressure: 1.15E-05mmHg at 25°C
• Melting Point: 123-125 °C(lit.)
• Refractive Index: 1.604
• Boiling Point: 370 °C at 760 mmHg
• Flash Point: 75.1 °C
• PSA: 17.07000
• Density: 1.379 g/cm³
• LogP: 3.93120
• Storage Temp.: 0-6°C
• Sensitive.: Lachrymatory
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 273.99933
• Heavy Atom Count: 16
• Complexity: 225

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-4'-phenylacetophenone >98.0%(GC)(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Halogenated Polyaromatics
• Canonical SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)CBr

Technology Process of 2-Bromo-4'-phenylacetophenone

There total 16 articles about 2-Bromo-4'-phenylacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

biphenyl-4-acetaldehyde (92-91-1) → 2-Bromo-4'-phenylacetophenone (135-73-9)

Guidance literature:

With bromine; In 1,4-dioxane; diethyl ether; for 0.5h; Ambient temperature;

Reference yield: 87.0%

4-(bromoethynyl)-1,1′-biphenyl (1321929-32-1) → 2-Bromo-4'-phenylacetophenone (135-73-9)

Guidance literature:

With indium(III) triflate; water; In acetic acid; at 100 ℃; Sealed tube;

DOI:10.1016/j.tet.2016.04.049

Reference yield: 87.0%

4-ethynyl-1,1'-biphenyl (29079-00-3) → 2-Bromo-4'-phenylacetophenone (135-73-9)

Guidance literature:

4-ethynyl-1,1'-biphenyl; With methanol; gold(III) chloride; silver(I) triflimide; In 1,4-dioxane; at 45 ℃;

With N-Bromosuccinimide; In 1,4-dioxane; regioselective reaction;

DOI:10.1002/ejoc.201601416

upstream raw materials:

biphenyl-4-acetaldehyde

biphenyl

2-Bromoacetyl bromide

1-(4-phenyl-phenyl)-1-ethanol

Downstream raw materials:

2-biphenyl-4-yl-indolizine

2,6-dimethyl-4-(4-phenyl-phenacylmercapto)-pyrylium; bromide

1-(4'-phenylphenacyl)quinolinium bromide

(4-Phenylphenacyl)isoquinolinium bromide

Refernces

• 1、 Cheng, Feng-Chang,Yin, Long,Liu, Wei-Wei,Li, Qu-Xiang,Tang, Li-Juan,Shi, Da-Hua,Cao, Zhi-Ling. "Expedient synthesis of novel glycosyl thiazole derivatives". . p. 2113 - 2125. Retrieved 2015.
• 2、 Kang, Lei,Zhang, Jinlong,Yang, Huameng,Qian, Jinlong,Jiang, Gaoxi. "Base-Catalyzed Intramolecular Defluorination/O-Arylation Reaction for the Synthesis of 3-Fluoro-1,4-oxathiine 4,4-Dioxide". supporting information. p. 785 - 789. Retrieved 2021/04/09.
• 3、 Kim, Wansoo,Kim, Hun Young,Oh, Kyungsoo. "Oxidation Potential-Guided Electrochemical Radical-Radical Cross-Coupling Approaches to 3-Sulfonylated Imidazopyridines and Indolizines". . p. 15973 - 15991. Retrieved 2021/07/26.