5-hydroxyflufenamic acid

Base Information

• Chemical Name: 5-hydroxyflufenamic acid
• CAS No.: 39062-67-4
• Molecular Formula: C14H10 F3 N O3
• Molecular Weight: 297.234
• Hs Code.: 2922509090
• Mol file: 39062-67-4.mol

Synonyms:5-Hydroxyflufenamicacid

Chemical Property of 5-hydroxyflufenamic acid

Chemical Property:

• Vapor Pressure: 2.61E-07mmHg at 25°C
• Boiling Point: 405.7°Cat760mmHg
• PKA: 3.58±0.36(Predicted)
• Flash Point: 199.1°C
• PSA: 69.56000
• Density: 1.486g/cm³
• LogP: 3.92580

Purity/Quality:

5-HYDROXYFLUFENAMIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-hydroxyflufenamic acid

There total 7 articles about 5-hydroxyflufenamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-phenylmethoxy-2-[(3-trifluoromethylphenyl)amino]benzoic acid (39062-65-2) → 2-[[3-(trifluoromethyl)phenyl]amino]-5-hydroxybenzoic acid (39062-67-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 1.5h;

Reference yield:

5-(benzyloxy)-2-chlorobenzoic acid (39062-64-1) → 2-[[3-(trifluoromethyl)phenyl]amino]-5-hydroxybenzoic acid (39062-67-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 49.8 percent / K₂CO₃ / Cu powder / 2 h / 160 °C

2: 96 percent / H₂ / 10percent Pd/C / methanol / 1.5 h

With hydrogen; potassium carbonate; palladium on activated charcoal; copper; In methanol;

Reference yield:

2-chloro-5-hydroxybenzoic acid (56961-30-9) → 2-[[3-(trifluoromethyl)phenyl]amino]-5-hydroxybenzoic acid (39062-67-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / NaOH

2: 49.8 percent / K₂CO₃ / Cu powder / 2 h / 160 °C

3: 96 percent / H₂ / 10percent Pd/C / methanol / 1.5 h

With sodium hydroxide; hydrogen; potassium carbonate; palladium on activated charcoal; copper; In methanol;

upstream raw materials:

5-phenylmethoxy-2-[(3-trifluoromethylphenyl)amino]benzoic acid

2-chloro-5-nitrobenzoic acid

2-chloro-5-aminobenzoic acid

5-(benzyloxy)-2-chlorobenzoic acid

Refernces

• 1、 Boltze,Backer,Kreisfeld. "Synthesis and properties of nuclear hydroxylated derivatives of flufenamic acid and etofenamate". . p. 183 - 186. Retrieved 2007/10/02.