2-(4-hydroxyphenoxy)-2-methylpropionic acid

Base Information

• Chemical Name: 2-(4-hydroxyphenoxy)-2-methylpropionic acid
• CAS No.: 67648-64-0
• Molecular Formula: C10H12 O4
• Molecular Weight: 196.203
• Mol file: 67648-64-0.mol

Synonyms:2-(4-Hydroxyphenoxy)-2-methylpropanoicacid; 2-(4-Hydroxyphenoxy)-2-methylpropionic acid

Chemical Property of 2-(4-hydroxyphenoxy)-2-methylpropionic acid

Chemical Property:

• Vapor Pressure: 4.94E-06mmHg at 25°C
• Boiling Point: 367°Cat760mmHg
• Flash Point: 146.8°C
• PSA: 66.76000
• Density: 1.257g/cm³
• LogP: 1.63420

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-hydroxyphenoxy)-2-methylpropionic acid

There total 7 articles about 2-(4-hydroxyphenoxy)-2-methylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(4-hydroxyphenoxy)-2-methyl propionic acid ethyl ester (42806-90-6) → 2-(4-Hydroxyphenoxy)-2-methyl-propionic acid (67648-64-0)

Guidance literature:

With sodium hydroxide; In ethanol; for 2h; Ambient temperature;

DOI:10.1002/ardp.19893220603

Reference yield:

Clofibric acid (882-09-7) → 2-(4-Hydroxyphenoxy)-2-methyl-propionic acid (67648-64-0)

Guidance literature:

With 5% Pd/C; ozone; In water; at 25 ℃; under 760.051 Torr; Darkness;

DOI:10.1016/j.cattod.2014.03.050

Reference yield:

hydroquinone (123-31-9,8027-02-9) → 2-(4-Hydroxyphenoxy)-2-methyl-propionic acid (67648-64-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / K₂CO₃ / acetonitrile / 20 h / Heating

2: 92 percent / 7.5percent aq. NaOH / ethanol / 2 h / Ambient temperature

With sodium hydroxide; potassium carbonate; In ethanol; acetonitrile;

DOI:10.1002/ardp.19893220603

upstream raw materials:

α-(4-hydroxy-phenoxy)-isobutyronitrile

dimethyl 2,2'-azobis(isobutyrate)

p-benzoquinone

benzene

Refernces

• 1、 Oelschlaeger,Rothley,Hellwich,Schmidt. "The pharmacokinetics of antilipemic agents. 5. Is 2-(4-hydroxyphenoxy)-2-methylpropionic acid a metabolite of the antilipemic ciprofibrate?". . p. 337 - 342. Retrieved 2007/10/02.