Technology Process of 3H-Oxazolo[3,4-a]pyrazin-3-one,
hexahydro-1,1-diphenyl-7-(phenylmethyl)-
There total 2 articles about 3H-Oxazolo[3,4-a]pyrazin-3-one,
hexahydro-1,1-diphenyl-7-(phenylmethyl)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-benzyl-piperazine-1-carboxylic acid tert-butyl ester;
With
sec.-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
Inert atmosphere;
benzophenone;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 0.75h;
Inert atmosphere;
DOI:10.1021/acs.joc.7b00913
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: ethanol / 5 h / 75 °C
2.1: dmap; tetraethyl ammonium / dichloromethane / 0.5 h / 20 °C
3.1: sec.-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 2 h / -78 - -30 °C / Inert atmosphere
3.2: 16 h / -30 - 20 °C / Inert atmosphere
With
dmap; N,N,N,N,-tetramethylethylenediamine; tetraethyl ammonium; sec.-butyllithium;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/acs.jmedchem.0c02223
- Guidance literature:
-
7-benzyl-1,1-diphenyl-hexahydro-1H-[1,3]oxazolo[3,4-a]-piperazin-3-one;
With
carbonochloridic acid 1-chloro-ethyl ester;
In
1,2-dichloro-ethane;
at 60 ℃;
for 5h;
With
methanol;
for 2.5h;
Product distribution / selectivity;
Heating / reflux;