Technology Process of 6-chloro-2-(3,4-dichlorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine
There total 8 articles about 6-chloro-2-(3,4-dichlorophenyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
W-2 Raney Ni;
In
tetrahydrofuran; ethanol;
for 6h;
DOI:10.1021/jm00159a006
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 74 percent / NaOAc, Br2 / acetic acid / 1.) 80 deg C, 6 h, 2.) 23 deg C, 64 h
2: 1.) n-BuLi / 1.) ether, hexane, -70 deg C, 15 min, 2.) ether, hexane, THF, -65 deg C
3: 74 percent / 48percent HBr, HOAc / 0.25 h / 100 °C
4: 56 percent / H2 / W-2 Raney Ni / tetrahydrofuran; ethanol / 6 h
With
n-butyllithium; hydrogen bromide; hydrogen; bromine; sodium acetate; acetic acid;
W-2 Raney Ni;
In
tetrahydrofuran; ethanol; acetic acid;
DOI:10.1021/jm00159a006
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) n-BuLi / 1.) ether, hexane, -70 deg C, 15 min, 2.) ether, hexane, THF, -65 deg C
2: 74 percent / 48percent HBr, HOAc / 0.25 h / 100 °C
3: 56 percent / H2 / W-2 Raney Ni / tetrahydrofuran; ethanol / 6 h
With
n-butyllithium; hydrogen bromide; hydrogen; acetic acid;
W-2 Raney Ni;
In
tetrahydrofuran; ethanol;
DOI:10.1021/jm00159a006
