3-Azetidinecarboxylic acid, 1-[[3,4-dihydro-1-methyl-6-(4-phenylbutoxy)-2-naphthalenyl]methyl]-, hydrochloride

Base Information

• Chemical Name: 3-Azetidinecarboxylic acid, 1-[[3,4-dihydro-1-methyl-6-(4-phenylbutoxy)-2-naphthalenyl]methyl]-, hydrochloride
• CAS No.: 847584-69-4
• Molecular Formula: C₂₆H₃₁NO₃*ClH
• Molecular Weight: 441.998
• Mol file: 847584-69-4.mol

Synonyms:

Chemical Property of 3-Azetidinecarboxylic acid, 1-[[3,4-dihydro-1-methyl-6-(4-phenylbutoxy)-2-naphthalenyl]methyl]-, hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Azetidinecarboxylic acid, 1-[[3,4-dihydro-1-methyl-6-(4-phenylbutoxy)-2-naphthalenyl]methyl]-, hydrochloride

There total 8 articles about 3-Azetidinecarboxylic acid, 1-[[3,4-dihydro-1-methyl-6-(4-phenylbutoxy)-2-naphthalenyl]methyl]-, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(4-phenylbutoxy)-3,4-dihydronaphthalen-1(2H)-one (847585-55-1) → 1-{[1-methyl-6-(4-phenylbutoxy)-3,4-dihydro-2-naphthalenyl]methyl}-3-azetidinecarboxylic acid hydrochloride (847584-69-4)

Guidance literature:

Multi-step reaction with 5 steps

1: tetrahydrofuran; diethyl ether

2: toluene-4-sulfonic acid / dichloromethane; water

3: trichlorophosphate / dichloromethane

4: sodium sulfate / tetrahydrofuran; methanol; isopropyl alcohol

5: hydrogenchloride / 1,4-dioxane; water

With hydrogenchloride; toluene-4-sulfonic acid; sodium sulfate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; isopropyl alcohol;

DOI:10.1016/j.bmcl.2011.05.029

Reference yield:

C21H26O2 (1314760-19-4) → 1-{[1-methyl-6-(4-phenylbutoxy)-3,4-dihydro-2-naphthalenyl]methyl}-3-azetidinecarboxylic acid hydrochloride (847584-69-4)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / dichloromethane; water

2: trichlorophosphate / dichloromethane

3: sodium sulfate / tetrahydrofuran; methanol; isopropyl alcohol

4: hydrogenchloride / 1,4-dioxane; water

With hydrogenchloride; toluene-4-sulfonic acid; sodium sulfate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; isopropyl alcohol;

DOI:10.1016/j.bmcl.2011.05.029

Reference yield:

1-{[1-methyl-6-(4-phenylbutoxy)-3,4-dihydronaphthalen-2-yl]methyl}azetidine-3-carboxylic acid (847586-08-7) → 1-{[1-methyl-6-(4-phenylbutoxy)-3,4-dihydro-2-naphthalenyl]methyl}-3-azetidinecarboxylic acid hydrochloride (847584-69-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water;

DOI:10.1016/j.bmcl.2011.05.029

upstream raw materials:

6-(4-phenylbutoxy)-3,4-dihydronaphthalen-1(2H)-one

C₂₁H₂₆O₂

4-methyl-7-(4-phenylbutoxy)-1,2-dihydronaphthalene

C₂₂H₂₄O₂

Refernces

• 1、 -. "COMPOUND CAPABLE OF BINDING S1P RECEPTOR AND PHARMACEUTICAL USE THEREOF". Page/Page column 96-97. . Retrieved 2010/11/08.