Hygromycin b

Base Information

• Chemical Name: Hygromycin b
• CAS No.: 31282-04-9
• Molecular Formula: C₂₀H₃₇N₃O₁₃
• Molecular Weight: 527.526
• Hs Code.: 29419059
• European Community (EC) Number: 250-545-5
• UN Number: 3462
• Wikipedia: Hygromycin_B
• Wikidata: Q418735
• Mol file: 31282-04-9.mol

Synonyms:Hygromycin B

Chemical Property of Hygromycin b

Chemical Property:

• Appearance/Colour: Amorphous solid or tan powder.
• Melting Point: 160-180 °C
• Refractive Index: 1.672
• Boiling Point: 897.6 °C at 760 mmHg
• PKA: 7.1, 8.8(at 25℃)
• Flash Point: 496.7 °C
• PSA: 272.06000
• Density: 1.67 g/cm³
• LogP: -5.47910
• Storage Temp.: 2-8°C
• Solubility.: H2O: 50 mg/mL As a stock solution. Stock solutions should b
• Water Solubility.: Miscible with water, methanol, buffer solution and ethanol. Immiscible with less polar solvents.
• XLogP3: -6.6
• Hydrogen Bond Donor Count: 11
• Hydrogen Bond Acceptor Count: 16
• Rotatable Bond Count: 6
• Exact Mass: 527.23263824
• Heavy Atom Count: 36
• Complexity: 756
• Transport DOT Label: Poison

Purity/Quality:

97%HPLC ^*data from raw suppliers

Hygromycin B, Streptomyces hygroscopicus ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T+, Xn
• Hazard Codes: T+,Xn,T
• Statements: 26/27/28-41-42/43-40-36-23/24/25
• Safety Statements: 23-26-28-36/37/39-45-22-36-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CNC1CC(C(C(C1O)OC2C3C(C(C(O2)CO)O)OC4(O3)C(C(C(C(O4)C(CO)N)O)O)O)O)N
• Isomeric SMILES: CN[C@H]1C[C@H]([C@@H]([C@H]([C@@H]1O)O[C@H]2[C@@H]3[C@H]([C@H]([C@H](O2)CO)O)OC4(O3)[C@@H]([C@@H]([C@H]([C@H](O4)[C@H](CO)N)O)O)O)O)N
• Description: Hygromycin B is an aminoglycoside antibiotic that has been found in S. hygroscopicus. It is active against E. coli (MIC = 150 μg/ml) and cytotoxic to both prokaryotic and eukaryotic cells via inhibition of protein synthesis. Hygromycin B has commonly been used in molecular and cell biology applications to select for transformed cells expressing the E. coli hygromycin resistance genes hyg or hph.
• Uses: antibacterial, anthelmintic; LD50 ip (rat) 63mg/Kg Hygromycin B, a selective antibiotic that is effective on most bacteria, fungi and higher eukaryotes, inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome Hygromycin B is an aminoglycoside and a selective antibiotic agent for the hph gene. Hygromycin B inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S rib osome Hygromycin B is a trisaccharide aminoglycoside with a terminal cyclitol produced by Streptomyces hygroscopicus, reported by researchers at Eli Lily in the early 1950s. Hygromycin B belongs to the destomycin family of aminoglycosides which contain a unique cyclic structure linking the terminal saccharide. Hygromycin B exhibits broad spectrum antibiotic and anthelmintic activity, and is used as a feed additive for swine and poultry. Hygromycin B inhibits polypeptide synthesis by binding peptidyl-tRNA and preventing translocation by Elongation Factor 2.