Diisopropyl carbonate

Base Information

• Chemical Name: Diisopropyl carbonate
• CAS No.: 6482-34-4
• Molecular Formula: C7H14 O3
• Molecular Weight: 146.186
• Hs Code.: 2920909090
• Mol file: 6482-34-4.mol

Synonyms:Carbonicacid, diisopropyl ester (6CI,7CI,8CI); Bis-2-propyl carbonate; Diisopropylcarbonate

Chemical Property of Diisopropyl carbonate

Chemical Property:

• Vapor Pressure: 1.39E-07mmHg at 25°C
• Melting Point: <25 °C
• Refractive Index: 1.525
• Boiling Point: 147 oC
• Flash Point: 53 ºC
• PSA: 35.53000
• Density: 0.945
• LogP: 1.95640
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), Ethyl Acetate

Purity/Quality:

99% ^*data from raw suppliers

DiisopropylCarbonate(StabilizedwithCalciumCarbonate) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Diisopropyl Carbonate is used in the synthesis of Huperizine A (H826000) a reversible alkaloid inhibitor of AChE which crosses the blood-brain barrier. A potential therapeutic agent for Alzheimer’s disease. It reduces cell death induced by glutamate in primary cultures derived from forebrain, hippocampus, cortex and cerebellum of embryonic rat brain.

Technology Process of Diisopropyl carbonate

There total 41 articles about Diisopropyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

bis(trichloromethyl) carbonate (32315-10-9) + isopropyl alcohol (67-63-0,8013-70-5) → bis-2-propyl carbonate (6482-34-4)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2009.07.015

Reference yield: 84.2%

methanol (67-56-1) + isopropyl N-hydroxycarbamate (27108-52-7) → methyl 1-methylethyl carbonate (51729-83-0) + bis-2-propyl carbonate (6482-34-4)

Guidance literature:

With lead dioxide; In dichloromethane; at 40 ℃; for 0.166667h;

DOI:10.1135/cccc19961053

Reference yield: 76.5%

isopropyl N-hydroxycarbamate (27108-52-7) + isopropyl alcohol (67-63-0,8013-70-5) → bis-2-propyl carbonate (6482-34-4)

Guidance literature:

With lead dioxide; In dichloromethane; at 40 ℃; for 0.166667h;

DOI:10.1135/cccc19961053

upstream raw materials:

diisopropyl pyrocarbonate

carbon monoxide

sodium isopropylate

isopropyl chloroformate

Downstream raw materials:

1-methyl-4,5-dihydro-5-(2-fluorophenyl)-2-isopropoxycarbonylaminoimidazole

1-methyl-4,5-dihydro-5-(2-chlorophenyl)-2-isopropoxycarbonylaminoimidazole

ethyl 2,2,2-trifluoroethyl carbonate

methyl (2,2,3,3-tetrafluoropropyl) carbonate

Refernces

• 1、 -. "METHOD FOR PRODUCING CARBONIC ESTER". Paragraph 0101-0118. . Retrieved 2021/03/05.
• 2、 Semenova, Anna M.,Ezhikova, Marina A.,Kodess, Mikhail I.,Zapevalov, Aleksandr Ya.,Pestov, Aleksandr V.. "Phosgene-free synthesis of symmetric bis(polyfluoroalkyl) carbonates". . p. 257 - 258. Retrieved 2021/05/04.