Pinazepam

Base Information

• Chemical Name: Pinazepam
• CAS No.: 52463-83-9
• Molecular Formula: C18H13 Cl N2 O
• Molecular Weight: 308.767
• Hs Code.: 2933910017
• European Community (EC) Number: 257-934-9
• UNII: 5286RBZ882
• DSSTox Substance ID: DTXSID3023475
• Nikkaji Number: J9.933C
• Wikipedia: Pinazepam
• Wikidata: Q7194856
• NCI Thesaurus Code: C66388
• Metabolomics Workbench ID: 49675
• ChEMBL ID: CHEMBL1213352
• Mol file: 52463-83-9.mol

Synonyms:7-chloro-5-phenyl-1-propargyl-1,4-benzodiazepin-2- one;Domar;Duna;pinazepam;propazepam;Z-905

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Chemical Property of Pinazepam

Chemical Property:

• Vapor Pressure: 4.66E-11mmHg at 25°C
• Melting Point: 140-142°
• Refractive Index: 1.5800 (estimate)
• Boiling Point: 523.6°C at 760 mmHg
• PKA: pKa 2.34 (Uncertain)
• Flash Point: 270.5°C
• PSA: 32.67000
• Density: 1.19g/cm³
• LogP: 2.65780
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 308.0716407
• Heavy Atom Count: 22
• Complexity: 501

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C#CCN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
• Uses: Pinazepam is a is a benzodiazepine. Pinazepam possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Pinazepam is less toxic than Diazepam. This is a contolled substance (depressant). Anxiolytic.
• Therapeutic Function: Antidepressant

Technology Process of Pinazepam

There total 2 articles about Pinazepam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

propargyl bromide (106-96-7) + desmethyldiazepam (1088-11-5) → pinazepam (52463-83-9)

Guidance literature:

In N-methyl-acetamide; hexane; chloroform; ethyl acetate; mineral oil; benzene;

Reference yield:

→ pinazepam (52463-83-9)

Guidance literature:

aus 7-Chlor-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-on und Propargylbromid;

Reference yield: 52.0%

mercaptoacetic acid (68-11-1) + pinazepam (52463-83-9) → 10-chloro-7,11b-dihydro-11b-phenyl-7-(2-propynyl)-thiazolo<3,2-d><1,4>benzodiazepine-3,6(2H,5H)-dione

Guidance literature:

In benzene; for 45h; Heating;

upstream raw materials:

propargyl bromide

desmethyldiazepam

Refernces

• 1、 Filippi,Trebbi. "Physicochemical profile of a new tranquillizer: Pinazepam". . p. 105 - 114,108,109,111. Retrieved 2007/10/09.