3-hydroxypropyl methanesulfonate

Base Information

• Chemical Name: 3-hydroxypropyl methanesulfonate
• CAS No.: 24590-50-9
• Molecular Formula: C4H10 O4 S
• Molecular Weight: 154.187
• Mol file: 24590-50-9.mol

Synonyms:1,3-Propanediol,monomethanesulfonate (8CI,9CI);3-Hydroxypropyl methanesulfonate;

Chemical Property of 3-hydroxypropyl methanesulfonate

Chemical Property:

• Vapor Pressure: 5.37E-06mmHg at 25°C
• Refractive Index: 1.458
• Boiling Point: 341.2°Cat760mmHg
• Flash Point: 160.2°C
• Density: 1.29g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-hydroxypropyl methanesulfonate

There total 3 articles about 3-hydroxypropyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

methanesulfonyl chloride (124-63-0) + trimethyleneglycol (504-63-2) → 1,3-dimesyloxypropane (15886-84-7) + 3-hydroxypropyl methanesulfonate (24590-50-9)

Guidance literature:

With triethylamine; In dichloromethane; at -10 ℃;

DOI:10.1016/S0960-894X(01)00626-6

Reference yield: 32.0%

methanesulfonyl chloride (124-63-0) + trimethyleneglycol (504-63-2) → 3-hydroxypropyl methanesulfonate (24590-50-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

DOI:10.1021/ol3009842

Reference yield:

→ 3-hydroxypropyl methanesulfonate (24590-50-9)

Guidance literature:

upstream raw materials:

methanesulfonyl chloride

trimethyleneglycol

Downstream raw materials:

3-azidopropan-1-ol

(1R,2S,3S,5S)-3-(4-Bromo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid 3-methanesulfonyloxy-propyl ester

(1R,2S,3S,5S)-3-(4-Iodo-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid 3-methanesulfonyloxy-propyl ester

(1R,2S,3S,5S)-8-Methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid 3-methanesulfonyloxy-propyl ester

Refernces

• 1、 Dey, Soumen,Karabal, Pratibha U.,Sudalai, Arumugam. "Concise Enantioselective Synthesis of Naturally Active (S)-3-Hydroxypiperidine". supporting information. p. 1559 - 1565. Retrieved 2015/06/02.
• 2、 Gu, Xiao-Hui,Zong, Rushi,Kula, Nora S.,Baldessarini, Ross J.,Neumeyer, John L.. "Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: Potential positron emission tomography (PET) imaging agents for the dopamine transporter". . p. 3049 - 3053. Retrieved 2007/10/03.