2-Bromo-3,5-dichloropyridine

Base Information

• Chemical Name: 2-Bromo-3,5-dichloropyridine
• CAS No.: 14482-51-0
• Molecular Formula: C5H2BrCl2N
• Molecular Weight: 226.888
• Hs Code.: 2933399090
• European Community (EC) Number: 672-535-3
• DSSTox Substance ID: DTXSID90355733
• Nikkaji Number: J38.528J
• Wikidata: Q72454165
• Mol file: 14482-51-0.mol

Synonyms:2-Bromo-3,5-dichloropyridine;14482-51-0;3,5-Dichloro-2-Bromopyridine;Pyridine, 2-bromo-3,5-dichloro-;MFCD00233990;2-Bromo-3,5-dichloro-pyridine;2-bromo-3,5-dichloropyridin;SCHEMBL544483;DTXSID90355733;QCKPJWDIDCGQRB-UHFFFAOYSA-N;BCP22111;RB1046;AKOS000267456;AB05062;AC-9472;CS-W007790;GS-6730;SY012471;2-Bromo-3,5-dichloropyridine, AldrichCPR;A3142;AM20070043;B3734;FT-0637089;EN300-142157;Q-101222

Chemical Property of 2-Bromo-3,5-dichloropyridine

Chemical Property:

• Vapor Pressure: 5.17mmHg at 25°C
• Melting Point: 40-42 °C
• Refractive Index: 1.508
• Boiling Point: 243.3 °C at 760 mmHg
• PKA: -2.37±0.10(Predicted)
• Flash Point: 101 °C
• PSA: 12.89000
• Density: 1.848 g/cm³
• LogP: 3.15090
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 224.87477
• Heavy Atom Count: 9
• Complexity: 101

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-3,5-dichloropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 36/37/38-41-37/38-25
• Safety Statements: 26-45-39

MSDS Files:

Useful:

• Canonical SMILES: C1=C(C=NC(=C1Cl)Br)Cl

Technology Process of 2-Bromo-3,5-dichloropyridine

There total 7 articles about 2-Bromo-3,5-dichloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,3,5-trichloropyridine (16063-70-0) → 3,5-dichloro-2-bromopyridine (14482-51-0)

Guidance literature:

With trimethylsilyl bromide; In propiononitrile; at 100 ℃; for 14h;

Reference yield: 76.0%

3,5-dichloropyridin-2-amine (4214-74-8) → 3,5-dichloro-2-bromopyridine (14482-51-0)

Guidance literature:

Reference yield: 61.0%

3,5-dichloropyridine-2-carboxylic acid (81719-53-1) → 3,5-dichloro-2-bromopyridine (14482-51-0)

Guidance literature:

With tert-butylhypochlorite; dichloromethane; oxygen; sodium hydrogencarbonate; at 70 ℃; for 20h; Green chemistry;

DOI:10.1039/c9gc02407g

upstream raw materials:

3,5-dichloropyridin-2-amine

4-bromo-3,5-dichloropyridine

2,4,4-trichloro-4-formylbutyronitrile

2,3,5-trichloropyridine

Downstream raw materials:

N-(2-(3,5-dichloropyridin-2-yl)ethyl)-2-(trifluoromethyl)benzamide

2-Cyano-3,5-dichloropyridine

3,5-dichloro-2-(trifluoromethyl)pyridine

Refernces

• 1、 -. "3. 5 - Dichloro -2 - cyano pyridine synthesis method". Paragraph 0031-0037; 0043-0047; 0053-0057. . Retrieved 2019/01/08.
• 2、 -. "DIFLUOROETHYLPYRIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS". Paragraph 0239. . Retrieved 2016/02/16.