o-chlorophenylthioacetate

Base Information

• Chemical Name: o-chlorophenylthioacetate
• CAS No.: 18619-18-6
• Molecular Formula: C8H7 Cl O2 S
• Molecular Weight: 202.661
• Hs Code.: 2930909090
• Mol file: 18619-18-6.mol

Synonyms:Aceticacid, [(2-chlorophenyl)thio]- (9CI); Acetic acid, [(o-chlorophenyl)thio]-(8CI); (2-Chlorophenylsulfanyl)acetic acid; NSC 513490;[(2-Chlorophenyl)thio]acetic acid; o-Chlorophenyl thioacetate

Chemical Property of o-chlorophenylthioacetate

Chemical Property:

• Vapor Pressure: 5.81E-05mmHg at 25°C
• Boiling Point: 332.4°Cat760mmHg
• Flash Point: 154.8°C
• PSA: 62.60000
• Density: 1.41g/cm³
• LogP: 2.51670

Purity/Quality:

99% ^*data from raw suppliers

2-[(2-chlorophenyl)sulfanyl]aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of o-chlorophenylthioacetate

There total 15 articles about o-chlorophenylthioacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl 2-(2-chlorophenyl)sulfanylacetate → (2-chloro-phenylsulfanyl)-acetic acid (18619-18-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 15h;

DOI:10.1021/acs.jmedchem.1c00888

Reference yield: 61.0%

2-chlorothiphenol (6320-03-2) + ethyl bromoacetate (105-36-2) → (2-chloro-phenylsulfanyl)-acetic acid (18619-18-6)

Guidance literature:

2-chlorothiphenol; ethyl bromoacetate; With potassium hydroxide; In ethanol; at 20 ℃; for 18h;

With ethanol; water; for 3h;

With hydrogenchloride; water; at 4 ℃; for 2h; pH=1;

Reference yield: 35.0%

mercaptoacetic acid (68-11-1) + o-chloroaniline (95-51-2) → (2-chloro-phenylsulfanyl)-acetic acid (18619-18-6)

Guidance literature:

o-chloroaniline; With hydrogenchloride; sodium nitrite;

mercaptoacetic acid; for 2h; Heating;

upstream raw materials:

2-chlorothiphenol

sodium monochloroacetic acid

2-aminophenylthioacetic acid

chloroacetic acid

Refernces

• 1、 Lee, Jiann-Fong,Chang, Ting-Yu,Liu, Zheng-Fang,Lee, Nian-Zhe,Yeh, Yen-Hsiu,Chen, Yi-Song,Chen, Tsung-Chih,Chou, Hao-Syun,Li, Tsai-Kun,Lee, Sung-Bau,Lin, Mei-Hsiang. "RETRACTED ARTICLE: Design, synthesis, and biological evaluation of heterotetracyclic quinolinone derivatives as anticancer agents targeting topoisomerases". . . Retrieved 2020/02/11.
• 2、 Ozhathil, Lijo Cherian,Delalande, Clémence,Bianchi, Beatrice,Nemeth, Gabor,Kappel, Sven,Thomet, Urs,Ross-Kaschitza, Daniela,Simonin, Céline,Rubin, Matthias,Gertsch, Jürg,Lochner, Martin,Peinelt, Christine,Reymond, Jean-Louis,Abriel, Hugues. "Identification of potent and selective small molecule inhibitors of the cation channel TRPM4". supporting information. p. 2504 - 2519. Retrieved 2018/05/03.