2-AMINO-3-PHENYLBUTANOIC ACID HYDROCHLORIDE

Base Information

• Chemical Name: 2-AMINO-3-PHENYLBUTANOIC ACID HYDROCHLORIDE
• CAS No.: 80997-87-1
• Molecular Formula: C10H14ClNO2
• Molecular Weight: 215.68
• Hs Code.: 29224985
• Mol file: 80997-87-1.mol

Synonyms:DL-Phenylalanine,b-methyl-, hydrochloride;Phenylalanine, b-methyl-,hydrochloride (9CI);b-Methylphenylalanine hydrochloride (1:1);

Chemical Property of 2-AMINO-3-PHENYLBUTANOIC ACID HYDROCHLORIDE

Chemical Property:

• Appearance/Colour: White powder to beige powder
• Vapor Pressure: 3.85E-05mmHg at 25°C
• Melting Point: 210 °C(lit.)
• Boiling Point: 338.4 °C at 760 mmHg
• Flash Point: 158.4 °C
• PSA: 63.32000
• LogP: 2.70430

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-3-phenylbutanoicacidHCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-3-PHENYLBUTANOIC ACID HYDROCHLORIDE

There total 6 articles about 2-AMINO-3-PHENYLBUTANOIC ACID HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

diethyl (acetylamino)(1-phenylethyl)malonate (59850-50-9) → 2-amino-3-phenylbutanoic acid hydrochloride (80997-87-1,59850-51-0)

Guidance literature:

With hydrogenchloride; at 90 - 100 ℃; for 16h;

DOI:10.1021/jo070878+

Reference yield:

diethyl (acetylamino)(1-phenylvinyl)malonate (949887-00-7) → 2-amino-3-phenylbutanoic acid hydrochloride (80997-87-1,59850-51-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd on carbon / ethanol / 2 h / 20 - 25 °C / 2585.81 Torr

2: 75 percent / aq. HCl / 16 h / 90 - 100 °C

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jo070878+

Reference yield:

phenylacetylene (536-74-3) → 2-amino-3-phenylbutanoic acid hydrochloride (80997-87-1,59850-51-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / indium(III) triflate; N-methylmorpholine / 3 h / 130 - 140 °C

2: 100 percent / H₂ / Pd on carbon / ethanol / 2 h / 20 - 25 °C / 2585.81 Torr

3: 75 percent / aq. HCl / 16 h / 90 - 100 °C

With indium(III) triflate; 4-methyl-morpholine; hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jo070878+

upstream raw materials:

(1-bromoethyl)benzne

2-acetylaminomalonic acid diethyl ester

diethyl (acetylamino)(1-phenylethyl)malonate

diethyl (acetylamino)(1-phenylvinyl)malonate

Refernces

• 1、 Angell, Paul,Blazecka, Peter G.,Lovdahl, Mark,Zhang, Ji. "Indium(III)-catalyzed addition of diethyl acetamidomalonate to terminal alkynes: An efficient approach to β-branched α-amino acids". . p. 6606 - 6609. Retrieved 2008/02/10.
• 2、 Kataok,Seto,Yamamoto,et al.. "Studies of unusual aminoacids and their peptides. VI. The syntheses and the optical resolutions of β methylphenylalanine and its dipeptide present in bottromycin". . p. 1081 - 1084. Retrieved 2007/10/06.