4-Chloro-2,5-diphenyloxazole

Base Information

• Chemical Name: 4-Chloro-2,5-diphenyloxazole
• CAS No.: 29431-45-6
• Molecular Formula: C15H10 Cl N O
• Molecular Weight: 255.703
• DSSTox Substance ID: DTXSID6067468
• Nikkaji Number: J422.229F
• Wikidata: Q81994065
• Mol file: 29431-45-6.mol

Synonyms:4-Chloro-2,5-diphenyloxazole;29431-45-6;4-chloro-2,5-diphenyl-1,3-oxazole;Oxazole, 4-chloro-2,5-diphenyl-;4-Chloro-2,5-diphenyl-oxazole;DTXSID6067468;SCHEMBL11454303;STK370943;AKOS005445810

Chemical Property of 4-Chloro-2,5-diphenyloxazole

Chemical Property:

• Vapor Pressure: 3.62E-06mmHg at 25°C
• Boiling Point: 397.5°C at 760 mmHg
• Flash Point: 194.2°C
• PSA: 26.03000
• Density: 1.229g/cm³
• LogP: 4.66200
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 255.0450916
• Heavy Atom Count: 18
• Complexity: 261

Purity/Quality:

4-CHLORO-2,5-DIPHENYL-OXAZOLE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=C(N=C(O2)C3=CC=CC=C3)Cl

Technology Process of 4-Chloro-2,5-diphenyloxazole

There total 6 articles about 4-Chloro-2,5-diphenyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2-oxo-2-phenylethyl)benzamide (4190-14-1) → 4-chloro-2,5-diphenyl-oxazole (29431-45-6)

Guidance literature:

With phosphorus pentachloride; at 170 ℃;

Reference yield:

2-benzoylamino-2-hydroxy-1-phenyl-ethanone (2166-87-2) → 4-chloro-2,5-diphenyl-oxazole (29431-45-6)

Guidance literature:

With phosphorus pentachloride; In benzene;

Reference yield:

2-aminoacetophenone hydrochloride (5468-37-1) → 4-chloro-2,5-diphenyl-oxazole (29431-45-6)

Guidance literature:

Multi-step reaction with 2 steps

1: glacial acetic acid; sodium acetate

2: phosphorus pentachloride / 170 °C

With phosphorus pentachloride; sodium acetate; acetic acid;

upstream raw materials:

N-(2-oxo-2-phenylethyl)benzamide

2-benzoylamino-2-hydroxy-1-phenyl-ethanone

phosphorus pentachloride

2-aminoacetophenone hydrochloride

Downstream raw materials:

2,5-diphenyloxazole