4-Tetradecylmorpholine

Base Information

• Chemical Name: 4-Tetradecylmorpholine
• CAS No.: 25727-93-9
• Molecular Formula: C18H37 N O
• Molecular Weight: 283.498
• Hs Code.: 2934999090
• European Community (EC) Number: 247-213-7
• DSSTox Substance ID: DTXSID0067131
• Nikkaji Number: J285.796K
• Wikidata: Q81993710
• ChEMBL ID: CHEMBL4096168
• Mol file: 25727-93-9.mol

Synonyms:4-Tetradecylmorpholine;25727-93-9;Morpholine, 4-tetradecyl-;EINECS 247-213-7;SCHEMBL8958014;CHEMBL4096168;DTXSID0067131;AKOS024390915;F87926

Chemical Property of 4-Tetradecylmorpholine

Chemical Property:

• Vapor Pressure: 1.5E-05mmHg at 25°C
• Melting Point: 17 °C
• Boiling Point: 366.1°Cat760mmHg
• PKA: 7.61±0.10(Predicted)
• Flash Point: 108°C
• PSA: 12.47000
• Density: 0.874g/cm³
• LogP: 4.95760
• XLogP3: 6.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 13
• Exact Mass: 283.287514804
• Heavy Atom Count: 20
• Complexity: 190

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCCCCN1CCOCC1

Technology Process of 4-Tetradecylmorpholine

There total 2 articles about 4-Tetradecylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

morpholine (110-91-8,99108-56-2) + 1-Bromotetradecane (112-71-0) → N-tetradecyl morpholine (25727-93-9)

Guidance literature:

With sodium hydroxide; In water; at 130 ℃; for 7h;

DOI:10.1016/j.molliq.2020.113506

Reference yield:

1-morpholino-1-oxotetradecane (5338-53-4) → N-tetradecyl morpholine (25727-93-9)

Guidance literature:

With lithium aluminium tetrahydride; sulfuric acid; In tetrahydrofuran; at 0 ℃;

DOI:10.1248/cpb.40.3234

Reference yield: 60.0%

N-tetradecyl morpholine (25727-93-9) + bromopropargyl p-toluenesulfonate → 4-Bromopropargyl-4-tetradecyl-morpholinium p-toluenesulfonate

Guidance literature:

In hexane; acetone;

upstream raw materials:

morpholine

1-Bromotetradecane

1-morpholino-1-oxotetradecane

Downstream raw materials:

4-ethyl-4-tetradecyl-morpholinium; ethyl sulfate

Refernces

• 1、 Zheng, Le-Chi,Tong, Qing-Xiao. "Synthesis, surface adsorption, micellization behavior and antibacterial activity of novel gemini surfactants with morpholinium headgroup and benzene-based spacer". . . Retrieved 2021/03/09.
• 2、 Kiuchi,Nishizawa,Kawanishi,Kinoshita,Ohsima,Uchitani,Sekino,Ishida,Kondo,Tsuda. "Nematocidal activity of long alkyl chain amides, amines and their derivatives on dog roundworm larvae". . p. 3234 - 3244. Retrieved 2007/10/02.