39989-43-0

Base Information

• Chemical Name: 39989-43-0
• CAS No.: 78335-91-8
• Molecular Formula: C7H7Cl2N
• Molecular Weight: 176.0432
• Mol file: 78335-91-8.mol

Synonyms:

Chemical Property of 39989-43-0

Chemical Property:

• Boiling Point: 251.3°Cat760mmHg
• Flash Point: 105.8°C
• Density: 1.32g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 39989-43-0

There total 2 articles about 39989-43-0 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1,3-dichloro-5-chloromethyl-benzene (3290-06-0) → (3,5-dichlorophenyl)methanammonium chloride (78335-91-8)

Guidance literature:

With ammonium hydroxide; In methanol; at 160 ℃; for 0.166667h; under 18100.7 Torr; chemoselective reaction; Flow reactor;

DOI:10.1021/acs.joc.8b02387

Reference yield:

3,5-dichlorobenzonitrile (6575-00-4) → (3,5-dichlorophenyl)methanammonium chloride (78335-91-8)

Guidance literature:

3,5-dichlorobenzonitrile; With hydrogen; C₂₀H₄₀MoN₂O₂P₂; sodium triethylborohydride; In tetrahydrofuran; toluene; at 100 ℃; for 24h; under 37503.8 Torr; Autoclave;

With hydrogenchloride; In diethyl ether; water;

DOI:10.1002/cctc.202000736

Reference yield:

potassium cyanate (590-28-3) + (3,5-dichlorophenyl)methanammonium chloride (78335-91-8) → (3,5-dichlorobenzylamine) monocarboxamide

Guidance literature:

In water; 1.) 50-60 deg C, 15 min; 2.) 1 h;

upstream raw materials:

1,3-dichloro-5-chloromethyl-benzene

3,5-dichlorobenzonitrile

Refernces

• 1、 Audubert, Clément,Bouchard, Alexanne,Mathieu, Gary,Lebel, Hélène. "Chemoselective Synthesis of Amines from Ammonium Hydroxide and Hydroxylamine in Continuous Flow". . p. 14203 - 14209. Retrieved 2019/01/21.