Isoxazole, 5-[1,1'-biphenyl]-4-yl-

Base Information

• Chemical Name: Isoxazole, 5-[1,1'-biphenyl]-4-yl-
• CAS No.: 84864-17-5
• Molecular Formula: C15H11NO
• Molecular Weight: 221.258
• Mol file: 84864-17-5.mol

Synonyms:

Chemical Property of Isoxazole, 5-[1,1'-biphenyl]-4-yl-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Isoxazole, 5-[1,1'-biphenyl]-4-yl-

There total 4 articles about Isoxazole, 5-[1,1'-biphenyl]-4-yl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

3-(<1,1'-biphenyl>-4-yl)-3-oxopropionaldehyde oxime (84864-25-5) → 5-(<1,1'-biphenyl>-4-yl)-isoxazole (84864-17-5)

Guidance literature:

With acetyl chloride; In tetrahydrofuran; for 1h; Ambient temperature;

DOI:10.1021/jm00359a015

Reference yield: 42.0%

3-([1,1'-biphenyl]-4-yl)prop-2-yn-1-ol (210885-00-0) → 3-([1,1'-biphenyl]-4-yl)isoxazole + 5-(<1,1'-biphenyl>-4-yl)-isoxazole (84864-17-5)

Guidance literature:

With bismuth(lll) trifluoromethanesulfonate; Iodine monochloride; N-benzyl hydroxylalmine; In 1,4-dioxane; at 101 ℃; for 5h; Sealed tube;

Reference yield:

biphenyl-4-acetaldehyde (92-91-1) → 5-(<1,1'-biphenyl>-4-yl)-isoxazole (84864-17-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 12 h / 110 °C / Sealed tube

2: hydroxylamine hydrochloride / ethanol / 1 h / Reflux; Sealed tube

With hydroxylamine hydrochloride; In ethanol;

DOI:10.1021/acs.orglett.8b04130

upstream raw materials:

3-(<1,1'-biphenyl>-4-yl)-3-oxopropionaldehyde oxime

biphenyl-4-acetaldehyde

3-(dimethylamino)-1-(biphenyl-4-yl)-2-propen-1-one

3-([1,1'-biphenyl]-4-yl)prop-2-yn-1-ol

Downstream raw materials:

3-(Biphenyl-4-carbonyl)-4-hydroxy-pyrrole-2,5-dione

3-(<1,1'-biphenyl>-4-yl)-3-oxopropionitrile

Refernces

• 1、 -. "Preparation method of isoxazole derivative". Paragraph 0048-0053. . Retrieved 2019/12/02.