Sinomenine hydrochloride

Base Information

• Chemical Name: Sinomenine hydrochloride
• CAS No.: 6080-33-7
• Molecular Formula: C₁₉H₂₃NO₄*ClH
• Molecular Weight: 365.857
• Hs Code.: 29334900
• European Community (EC) Number: 683-119-6
• NSC Number: 76021
• UNII: 2J34HRJ45S
• Wikidata: Q27254812
• Mol file: 6080-33-7.mol

Synonyms:4-hydroxy-3,7-dimethoxy-17-methylmorphin-7-en- 6-one;cocculine;cucoline;cucoline hydrochloride;cucoline, hydrochloride;cuculine;kukoline;morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, (9alpha,13alpha,14alpha)-;morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, hydrochloride (1:1), (9alpha,13alpha,14alpha)-;NSC-76021;sinomenin hydrochloride;sinomenine;sinomenine A bismethyliodide;sinomenine hydrochloride

Chemical Property of Sinomenine hydrochloride

Chemical Property:

• Vapor Pressure: 3.59E-11mmHg at 25°C
• Melting Point: 231.0 to 235.0 °C
• Boiling Point: 536 °C at 760 mmHg
• Flash Point: 278 °C
• PSA: 59.00000
• LogP: 2.75800
• Storage Temp.: 2-8°C
• Solubility.: H2O: soluble20mg/mL, clear
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 365.1393859
• Heavy Atom Count: 25
• Complexity: 562

Purity/Quality:

99%, ^*data from raw suppliers

Sinomenine hydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC23CC(=O)C(=CC2C1CC4=C3C(=C(C=C4)OC)O)OC.Cl
• Isomeric SMILES: CN1CC[C@@]23CC(=O)C(=C[C@@H]2[C@@H]1CC4=C3C(=C(C=C4)OC)O)OC.Cl
• Description: Sinomenine is a natural plant alkaloid commonly used to alleviate inflammation associated with rheumatoid arthritis. It activates histamine release, reduces joint stiffness and pain, and alters cytokine generation without producing gastrointestinal adverse events. Sinomenine also impairs signaling through NF-κB, resulting in immunosuppression as well as reduced inflammation and pain. It enhances the bioavailability of some compounds, at least in part through an inhibition of drug export by transporters like P-glycoprotein.
• Uses: Sinomenine is an optical isomer of Methoxythebainone. Sinomenine was extracted from root of Sinomenium acutum. Sinomenine has anti-inflammatory and analgesic effect.