Meptin

Base Information

• Chemical Name: Meptin
• CAS No.: 62929-91-3
• Molecular Formula: C16H22N2O3^.HCl
• Molecular Weight: 326.86
• Hs Code.: 2933790090
• European Community (EC) Number: 263-763-0
• UNII: 4VD1BRT7T8
• NCI Thesaurus Code: C166789
• Mol file: 62929-91-3.mol

Synonyms:(R*,S*)-(+-)-8-Hydroxy-5-(1-hydroxy-2-((1-methylethyl)amino)butyl)-2(1H)-quinolinone;CI 888;CI-888;CI888;Hydrochloride, Procaterol;Monohydrochloride, Procaterol;OPC 2009;OPC-2009;OPC2009;Pro Air;Pro-Air;ProAir;Procaterol;Procaterol Hydrochloride;Procaterol Monohydrochloride;Procaterol Monohydrochloride, (R*,R*)-(+)-Isomer;Procaterol Monohydrochloride, (R*,R*)-(+-)-Isomer;Procaterol Monohydrochloride, (R*,R*)-(-)-Isomer;Procaterol Monohydrochloride, (R*,S*)-(+)-Isomer;Procaterol Monohydrochloride, (R*,S*)-(-)-Isomer;Procaterol, (R*,R*)-(+-)-Isomer;Procaterol, (R*,S*)-(-)-Isomer

Chemical Property of Meptin

Chemical Property:

• Vapor Pressure: 1.79E-12mmHg at 25°C
• Boiling Point: 539.5 °C at 760 mmHg
• Flash Point: 280.1 °C
• PSA: 85.35000
• LogP: 3.23660
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 326.1397203
• Heavy Atom Count: 22
• Complexity: 397

Purity/Quality:

99.9% ^*data from raw suppliers

Procaterol hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C(C1=C2C=CC(=O)NC2=C(C=C1)O)O)NC(C)C.Cl
• Isomeric SMILES: CC[C@H]([C@H](C1=C2C=CC(=O)NC2=C(C=C1)O)O)NC(C)C.Cl
• Recent ClinicalTrials: Efficacy and Safety Study of Procaterol Hydrochloride to Treat Patients With Cough Variant Asthma (CVA)
• Recent NIPH Clinical Trials: Therapeutic efficacy of budesonide inhalation suspension for moderate bronchial asthma attacks as a substitute for steroid injection
• Description: Procaterol is an agonist of β2-adrenergic receptors (β2-ARs). It binds to (Kd = 46 pM), and is selective for, β2-ARs over β1-ARs (Kd = 4,000 pM). Procaterol binds more potently to β2-ARs in isolated guinea pig lung than to β1-ARs in isolated guinea pig cardiac ventricle in the presence (IC50s = 175 and 1,660 nM, respectively) and absence of GTP (; IC50s = 55.1 and 1,660 nM, respectively). It inhibits contractions induced by acetylcholine in isolated guinea pig trachea (EC50 = 10.5 nM). In vivo, procaterol inhibits histamine-induced airflow obstruction in a guinea pig model of ovalbumin-sensitized asthma when administered via inhalation at a dose of 10 μg/ml.
• Uses: adrenergic agonists Procaterol Hydrochloride is a short-acting pulmonary β2-agonist for asthma treatment.