1,3,4,6,7,8-hexahydro-2H-quinolizine

Base Information

• Chemical Name: 1,3,4,6,7,8-hexahydro-2H-quinolizine
• CAS No.: 6391-47-5
• Molecular Formula: C₉H₁₅N
• Molecular Weight: 137.225
• Mol file: 6391-47-5.mol

Synonyms:3,4,6,7,8,9-Hexahydro-2H-quinolizine;D1,10-Hexahydroquinolizine

Chemical Property of 1,3,4,6,7,8-hexahydro-2H-quinolizine

Chemical Property:

• Vapor Pressure: 0.0499mmHg at 25°C
• Boiling Point: 235.5°Cat760mmHg
• Flash Point: 87.7°C
• PSA: 3.24000
• Density: 0.98g/cm³
• LogP: 2.08790

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3,4,6,7,8-hexahydro-2H-quinolizine

There total 8 articles about 1,3,4,6,7,8-hexahydro-2H-quinolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl ether (60-29-7,927820-24-4) + isopropylmagnesium iodide (1068-56-0) + 1,2,3,4,6,7,8,9-octahydroquinolizin-5-ium perchlorate → quinolizidine (493-10-7) + 2,3,4,6,7,8-hexahydro-1H-quinolizine (6391-47-5)

Guidance literature:

DOI:10.1021/ja01590a062

Reference yield:

quinolizidine (493-10-7) → 2,3,4,6,7,8-hexahydro-1H-quinolizine (6391-47-5)

Guidance literature:

With mercury(II) diacetate; acetic acid;

DOI:10.1021/ja01607a064

Reference yield:

piperidin-2-one (675-20-7) → 2,3,4,6,7,8-hexahydro-1H-quinolizine (6391-47-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

1.2: Reflux

2.1: soda lime / 160 - 170 °C

With sodium hydride; In tetrahydrofuran;

DOI:10.1016/j.bmc.2014.11.028

upstream raw materials:

quinolizidine

mercury(II) diacetate

acetic acid

diethyl ether

Downstream raw materials:

10-Methyl-chinolizidin

quinolizidine

Refernces

• 1、 Barteselli, Anna,Casagrande, Manolo,Basilico, Nicoletta,Parapini, Silvia,Rusconi, Chiara M.,Tonelli, Michele,Boido, Vito,Taramelli, Donatella,Sparatore, Fabio,Sparatore, Anna. "Clofazimine analogs with antileishmanial and antiplasmodial activity". . p. 55 - 65. Retrieved 2015/01/16.