2'-AMINO-4',5'-DIMETHOXYACETOPHENONE

Base Information

• Chemical Name: 2'-AMINO-4',5'-DIMETHOXYACETOPHENONE
• CAS No.: 4101-30-8
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.218
• Hs Code.: 2922509090
• Mol file: 4101-30-8.mol

Synonyms:Acetophenone,2'-amino-4',5'-dimethoxy- (7CI,8CI);1-(2-Amino-4,5-dimethoxyphenyl)ethanone;2-Acetyl-4,5-dimethoxyaniline;4',5'-Dimethoxy-2'-aminoacetophenone;

Chemical Property of 2'-AMINO-4',5'-DIMETHOXYACETOPHENONE

Chemical Property:

• Melting Point: 106-108 °C
• Boiling Point: 343.5 °C at 760 mmHg
• PKA: 2.48±0.10(Predicted)
• Flash Point: 172.2 °C
• PSA: 61.55000
• Density: 1.14 g/cm³
• LogP: 2.06980
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

2''-Amino-4'',5''-Dimethoxyacetophenone ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2''-Amino-4'',5''-Dimethoxyacetophenone is a bird repellant.

Technology Process of 2'-AMINO-4',5'-DIMETHOXYACETOPHENONE

There total 15 articles about 2'-AMINO-4',5'-DIMETHOXYACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.7%

4',5'-dimethoxy-2'-nitroacetophenone (4101-32-0) → 2-amino-4,5-dimethoxyacetophenone (4101-30-8)

Guidance literature:

With iron; ammonium chloride; In water; ethyl acetate; at 20 ℃; for 4h; Temperature; Reagent/catalyst; Solvent;

Reference yield: 73.0%

3',4'-dimethoxyacetanilide (881-70-9) → 2-amino-4,5-dimethoxyacetophenone (4101-30-8) + 6'-amino-2',3'-dimethoxyacetophenone (98300-41-5)

Guidance literature:

With brij 35; In water; at 25 ℃; Reagent/catalyst; regioselective reaction; Irradiation; Micellar solution; Inert atmosphere;

DOI:10.1039/c5pp00349k

Reference yield: 51.0%

3',4'-dimethoxyacetanilide (881-70-9) → 2-amino-4,5-dimethoxyacetophenone (4101-30-8) + 6'-amino-2',3'-dimethoxyacetophenone (98300-41-5) + 3,4-dimethoxyaniline (6315-89-5)

Guidance literature:

In cyclohexane; at 25 ℃; Solvent; Inert atmosphere; Irradiation;

DOI:10.1039/c5pp00349k

upstream raw materials:

4',5'-dimethoxy-2'-nitroacetophenone

acetic acid

acetone

hydrogenchloride

Downstream raw materials:

acetic acid-(2-acetyl-4,5-dimethoxy-anilide)

4,5-dimethoxy-2-(1-methylethenyl)benzenamine

2-(2-Amino-4,5-dimethoxy-phenyl)-propan-2-ol

Ethylxanthogensaeure-(4,5-dimethoxy-2-acetyl-phenylester)

Refernces

• 1、 -. "Preparation method of intermediate of tyrosine kinase inhibitor". Paragraph 0022-0033. . Retrieved 2018/11/22.
• 2、 Iguchi, Daniela,Erra-Balsells, Rosa,Bonesi, Sergio M.. "Photo-Fries rearrangement of aryl acetamides: Regioselectivity induced by the aqueous micellar green environment". . p. 105 - 116. Retrieved 2016/01/20.