Remifentanil hydrochloride

Base Information Edit

Chemical Name:Remifentanil hydrochloride
CAS No.:132539-07-2
Molecular Formula:C20H28 N2 O5 . Cl H
Molecular Weight:412.914
Hs Code.:
European Community (EC) Number:638-766-9
UNII:5V444H5WIC
DSSTox Substance ID:DTXSID50157614
Wikidata:Q27114780
NCI Thesaurus Code:C47702
RXCUI:236540
ChEMBL ID:CHEMBL1201120
Mol file:132539-07-2.mol

Synonyms:3-(4-methoxycarbonyl-4-((1-oxopropyl)phenylamino)-1-piperidine)propanoic acid methyl ester;GI 87084B;GI-87084B;GI87084B;remifentanil;remifentanil hydrochloride;remifentanil monohydrochloride;Ultiva

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Remifentanil hydrochloride Edit

Chemical Property:

Vapor Pressure:1.15E-09mmHg at 25°C
Melting Point:195-197°C
Boiling Point:487.8°Cat760mmHg
Flash Point:248.8°C
PSA：76.15000
Density:g/cm³
LogP:2.74020
Storage Temp.:Controlled Substance, -20°C Freezer
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:412.1764997
Heavy Atom Count:28
Complexity:523

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCC(=O)OC)C(=O)OC.Cl
Recent ClinicalTrials:the Effect of Dexmedetomidine and Licodaine on Acute Postoperative Pain in Gynecological Laparoscopy
Recent EU Clinical Trials:Brain functional signature of connected consciousness under general anesthesia using the isolated forearm technique
Recent NIPH Clinical Trials:A Phase 3 Study of MR13A11A
Description Ultiva was launched in Germany and the US for use in general anesthesia and immediate post-operative pain management. This compound can be prepared via the Michael addition of a 4,4-disubstituted piperidine to methyl acrylate. It behaves as a specific μ-opiod agonist that is about 30 times more potent than its chemical relative alfentanil. While its pharmacodynamic properties are similar to other μ agonists, remifentanil has unique pharmacokinetic properties. It has a rapid onset (1.6 min) and a rapid offset (5.4 min) independent of duration of administration. This has been attributed to its rapid catabolism by general esterases to the corresponding acrylic acid derivative. The metabolite has 0.01 to 0.0005 times the activity of remifentanil and is excreted via the kidneys (80% recovery).
Uses Labelled synthetic mu-opioid agonist. This is a controlled substance (opiate)

Technology Process of Remifentanil hydrochloride

There total 9 articles about Remifentanil hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%