2-CHLOROMETHYLFLUORENE

Base Information

• Chemical Name: 2-CHLOROMETHYLFLUORENE
• CAS No.: 91679-67-3
• Molecular Formula: C₁₄H₁₁Cl
• Molecular Weight: 214.694
• Mol file: 91679-67-3.mol

Synonyms:2-(Chloromethyl)fluorene

Chemical Property of 2-CHLOROMETHYLFLUORENE

Chemical Property:

• Vapor Pressure: 4.97E-05mmHg at 25°C
• Boiling Point: 359.3°Cat760mmHg
• Flash Point: 162.9°C
• PSA: 0.00000
• Density: 1.219g/cm³
• LogP: 3.99660

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLOROMETHYLFLUORENE

There total 5 articles about 2-CHLOROMETHYLFLUORENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(9H-Fluoren-2-yl)-methanol (72322-00-0) → 2-Chloromethyl-9H-fluorene (91679-67-3)

Guidance literature:

With phosphorus pentachloride;

Reference yield:

9H-fluorene-2-carboxylic acid (7507-40-6) → 2-Chloromethyl-9H-fluorene (91679-67-3)

Guidance literature:

Multi-step reaction with 2 steps

1: LAH / diethyl ether / Heating

2: SOCl₂ / CH₂Cl₂ / Ambient temperature

With lithium aluminium tetrahydride; thionyl chloride; In diethyl ether; dichloromethane;

DOI:10.1016/S0960-894X(98)00361-8

Reference yield:

2-cyanofluorene (2523-48-0) → 2-Chloromethyl-9H-fluorene (91679-67-3)

Guidance literature:

Multi-step reaction with 3 steps

1: nickel; decalin / 100 °C / Hydrogenation_.unter Druck

2: sodium nitrite; acetic acid

3: phosphorus pentachloride

With phosphorus pentachloride; nickel; acetic acid; decalin; sodium nitrite;

upstream raw materials:

formaldehyd

9H-fluorene

(9H-Fluoren-2-yl)-methanol

9H-fluorene-2-carboxylic acid

Downstream raw materials:

[4-(9H-fluoren-2-ylmethylsulfanyl)-2-methyl-phenoxy]-acetic acid methyl ester

1-p-Dimethylamino-phenyl-2--ethylen

Refernces

• 1、 Arlt, Michael,Boettcher, Henning,Riethmueller, Angelika,Schneider, Guenter,Bartoszyk, Gerd D.,Greiner, Hartmut,Seyfried, Christoph A.. "SAR of novel biarylmethylamine dopamine D4 receptor ligands". . p. 2033 - 2038. Retrieved 2007/10/03.