3-FLUORO-DL-VALINE

Base Information

• Chemical Name: 3-FLUORO-DL-VALINE
• CAS No.: 43163-94-6
• Molecular Formula: C5H10FNO2
• Molecular Weight: 135.138
• Hs Code.: 2922499990
• Mol file: 43163-94-6.mol

Synonyms:2-Amino-3-fluoro-3-methylbutanoicacid;3-Fluoro-DL-valine;3-Fluorovaline;DL-b-Fluorovaline;NSC 363265;

Chemical Property of 3-FLUORO-DL-VALINE

Chemical Property:

• Vapor Pressure: 0.0115mmHg at 25°C
• Melting Point: ~210 °C (dec.)
• Refractive Index: 1.44
• Boiling Point: 242.1 °C at 760 mmHg
• PKA: 1.91±0.12(Predicted)
• Flash Point: 100.2 °C
• PSA: 63.32000
• Density: 1.172 g/cm³
• LogP: 0.84670
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Fluorovaline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25

MSDS Files:

Useful:

Technology Process of 3-FLUORO-DL-VALINE

There total 9 articles about 3-FLUORO-DL-VALINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

C13H16FNO4 (1620450-64-7) → 2-amino-3-fluoro-3-methylbutanoic acid (43163-94-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 25 ℃; for 6h; under 775.743 Torr;

Reference yield: 65.0%

amino-2 fluoro-3 methyl-3 butanonitrile (79205-57-5) → 2-amino-3-fluoro-3-methylbutanoic acid (43163-94-6)

Guidance literature:

With hydrogenchloride; In water; 1.) 0 deg C, 24 h; 2.) reflux, 4 h;

DOI:10.1016/S0022-1139(00)85199-4

Reference yield:

3-fluoro-2-hydroxy-3-methylbutanonitrile (26429-35-6) → 2-amino-3-fluoro-3-methylbutanoic acid (43163-94-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / NH₃, MgSO₄ / methanol / 168 h / Ambient temperature

2: 65 percent / conc. HCl / H₂O / 1.) 0 deg C, 24 h; 2.) reflux, 4 h

With hydrogenchloride; ammonia; magnesium sulfate; In methanol; water;

DOI:10.1016/S0022-1139(00)85199-4

upstream raw materials:

2-Bromo-3-fluoro-3-methyl-butyric acid

amino-2 fluoro-3 methyl-3 butanonitrile

3-fluoro-2-keto-3-methybutanoic acid

2-phenyl-4-isopropylidene-5(4H)oxazolone

Downstream raw materials:

C₁₃H₁₆FNO₄

C₁₃H₁₆FNO₄

C₁₃H₁₆FNO₄

tert-butyl 2-fluoro-1,2-dimethylpropyl carbamate

Refernces

• 1、 -. "THIAZOLYL-SUBSTITUED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES". Page/Page column 42. . Retrieved 2014/08/06.
• 2、 Ayi, A. I.,Guedj, R.. "STEREOSPECIFIC SYNTHESIS OF 2-AMINO-3-FLUORONITRILES. PREPARATION OF β-FLUORO-α-AMINO ACID AND ESTERS". . p. 137 - 152. Retrieved 2007/10/02.