Technology Process of Carbamic acid,
[[4-chloro-2-[[[[(2S)-1-[(5-hydroxy-5H-indeno[1,2-c]pyridin-5-yl)carbonyl]
-2-pyrrolidinyl]carbonyl]amino]methyl]phenyl]methyl]-, 1,1-dimethylethyl
ester
There total 11 articles about Carbamic acid,
[[4-chloro-2-[[[[(2S)-1-[(5-hydroxy-5H-indeno[1,2-c]pyridin-5-yl)carbonyl]
-2-pyrrolidinyl]carbonyl]amino]methyl]phenyl]methyl]-, 1,1-dimethylethyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-aza-9-hydroxy-9-fluorene carboxylic acid hydrazide;
With
hydrogenchloride; n-Amyl nitrite;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at -20 ℃;
(S)-tert-butyl 4-chloro-2-((pyrrolidine-2-carboxamido)methyl)benzylcarbamate;
With
N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at -20 ℃;
for 24h;
DOI:10.1021/jm049423s
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 90 percent / hydrazine / 2 h / 20 °C
2.1: HCl(gas); amyl nitrite / dimethylformamide; tetrahydrofuran / -20 °C
2.2: 13 percent / N,N-diisopropylethylamine / tetrahydrofuran; dimethylformamide / 24 h / -20 °C
With
hydrogenchloride; n-Amyl nitrite; hydrazine;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm049423s
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 2.2 g / HCl(gas) / 2 h / 20 °C
2.1: 90 percent / hydrazine / 2 h / 20 °C
3.1: HCl(gas); amyl nitrite / dimethylformamide; tetrahydrofuran / -20 °C
3.2: 13 percent / N,N-diisopropylethylamine / tetrahydrofuran; dimethylformamide / 24 h / -20 °C
With
hydrogenchloride; n-Amyl nitrite; hydrazine;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm049423s