Mono-iodo amiodarone

Base Information

• Chemical Name: Mono-iodo amiodarone
• CAS No.: 85642-08-6
• Molecular Formula: C₂₅H₃₀INO₃
• Molecular Weight: 519.423
• Mol file: 85642-08-6.mol

Synonyms:L 6355

Chemical Property of Mono-iodo amiodarone

Chemical Property:

• Boiling Point: 586.1±50.0 °C(Predicted)
• PKA: 9.47±0.25(Predicted)
• PSA: 42.68000
• Density: 1.345±0.06 g/cm3(Predicted)
• LogP: 6.33160
• Storage Temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99%min. ^*data from raw suppliers

DeiodoAmiodarone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An intermediate of Amiodarone (A632950). Amiodarone EP Impurity C

Technology Process of Mono-iodo amiodarone

There total 6 articles about Mono-iodo amiodarone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-chloro-N,N-diethylethylamine hydrochloride (869-24-9) + 2-n-butyl-3-(3-iodo-4-hydroxybenzoyl)-benzofuran (147030-50-0) → Deiodoamiodarone (85642-08-6)

Guidance literature:

With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2008.08.013

Reference yield:

2-n-Butyl-3-(4-hydroxy-benzoyl)-benzofuran (52490-15-0) → Deiodoamiodarone (85642-08-6)

Guidance literature:

Multi-step reaction with 2 steps

1: I₂; HIO₃ / acetic acid

2: sodium ethoxide

With iodine; sodium ethanolate; iodic acid; In acetic acid;

DOI:10.1007/s002280050701

Reference yield:

Amiodarone (1951-25-3) → desethylamiodarone (83409-32-9) + Deiodoamiodarone (85642-08-6)

Guidance literature:

With ammonium hydroxide; ammonium formate; In acetonitrile; Reactivity; Electrochemical reaction;

DOI:10.1021/ac801878k

upstream raw materials:

2-(diethylamino)ethyl chloride

2-n-butyl-3-(3-iodo-4-hydroxybenzoyl)-benzofuran

2-n-Butyl-3-(4-hydroxy-benzoyl)-benzofuran

2-chloro-N,N-diethylethylamine hydrochloride

Refernces

• 1、 Lohmann, Wiebke,Meermann, Bjoern,Moeller, Ines,Scheffer, Andy,Karst, Uwe. "Quantification of electrochemically generated iodine-containing metabolites using inductively coupled plasma mass spectrometry". experimental part. p. 9769 - 9775. Retrieved 2009/07/11.