Taprostene

Base Information

• Chemical Name: Taprostene
• CAS No.: 108945-35-3
• Molecular Formula: C₂₄H₃₀O₅
• Molecular Weight: 398.499
• UNII: 7MS1HEY2IZ
• DSSTox Substance ID: DTXSID50872496
• Nikkaji Number: J339.292I
• Wikidata: Q27088939
• NCI Thesaurus Code: C76403
• Pharos Ligand ID: F1VMW9HZVCDF
• ChEMBL ID: CHEMBL2104890
• Mol file: 108945-35-3.mol

Synonyms:2,3,4-trinor-1,5-inter-2-phenylene-6,9-epoxy-11,15-dihydroxy-15-dihydroxy-15-cyclohexyl-(16,17,18,19,20-pentanor)prosta-5,13-dienoate;CG 4203;CG-4203;sodium 2,3,4-trinor-1,5-2-phenylene-6,9-epoxy-11,15-dihydroxy-15-cyclohexyl-(16,17,18,19,20-pentanor)prosta-5,13-dienoate;taprostene

Chemical Property of Taprostene

Chemical Property:

• Vapor Pressure: 1.06E-15mmHg at 25°C
• Boiling Point: 609.4°Cat760mmHg
• Flash Point: 209.2°C
• PSA: 86.99000
• Density: 1.305g/cm³
• LogP: 4.00900
• XLogP3: 4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 398.20932405
• Heavy Atom Count: 29
• Complexity: 635

Purity/Quality:

99.0%min ^*data from raw suppliers

Taprostene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)C(C=CC2C(CC3C2CC(=CC4=CC(=CC=C4)C(=O)O)O3)O)O
• Isomeric SMILES: C1CCC(CC1)[C@@H](/C=C/[C@H]2[C@@H](C[C@H]3[C@@H]2C/C(=C/C4=CC(=CC=C4)C(=O)O)/O3)O)O
• Description: Taprostene is a stable prostacyclin (PGI2) analog and agonist of the prostacyclin receptor, IP. It does not activate the PGE2 receptor EP4, which, like IP, promotes vascular smooth muscle relaxation when stimulated. Taprostene has been used extensively to study the role of the IP receptor in tissue preparations and in vivo. It has also been used in the screening and evaluation of potential IP antagonists.