2-(Tritylsulfanyl)ethanol

Base Information

• Chemical Name: 2-(Tritylsulfanyl)ethanol
• CAS No.: 29167-28-0
• Molecular Formula: C21H20 O S
• Molecular Weight: 320.455
• NSC Number: 129857
• DSSTox Substance ID: DTXSID80299379
• Nikkaji Number: J1.691.392H
• Wikidata: Q82041750
• ChEMBL ID: CHEMBL272034
• Mol file: 29167-28-0.mol

Synonyms:2-(tritylsulfanyl)ethanol;29167-28-0;2-(tritylthio)ethanol;Ethanol, 2-[(triphenylmethyl)thio]-;2-tritylsulfanylethanol;Ethanol,2-[(triphenylmethyl)thio]-;NSC129857;SCHEMBL974722;2-(triphenylmethylthio)ethanol;CHEMBL272034;BDBM23797;DTXSID80299379;OSBZFOJENKWGPX-UHFFFAOYSA-N;NSC-129857;Triphenylmethyl-containing compound, 26;2-[(triphenylmethyl)sulfanyl]ethan-1-ol;F70078;A904003

Chemical Property of 2-(Tritylsulfanyl)ethanol

Chemical Property:

• Vapor Pressure: 2.19E-09mmHg at 25°C
• Boiling Point: 463.4°Cat760mmHg
• Flash Point: 224.8°C
• Density: 1.155g/cm³
• XLogP3: 4.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 320.12348643
• Heavy Atom Count: 23
• Complexity: 279

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)SCCO

Technology Process of 2-(Tritylsulfanyl)ethanol

There total 6 articles about 2-(Tritylsulfanyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

trityl chloride (76-83-5) + 2-hydroxyethanethiol (60-24-2) → triphenylmethyl sulfanylethyl alcohol (29167-28-0)

Guidance literature:

In tetrahydrofuran; at 50 ℃; for 4h;

DOI:10.1002/anie.201507186

Reference yield: 85.0%

triphenylmethyl alcohol (76-84-6) + 2-hydroxyethanethiol (60-24-2) → triphenylmethyl sulfanylethyl alcohol (29167-28-0)

Guidance literature:

With trifluoroacetic acid; In chloroform; at 20 ℃; for 2h;

DOI:10.1021/ol202047q

Reference yield: 67.0%

2-Trityloxyethyl-tritylsulfid (29167-29-1) → triphenylmethyl sulfanylethyl alcohol (29167-28-0)

Guidance literature:

With hydrogenchloride; In acetonitrile; for 0.0833333h;

DOI:10.1021/jo0156971

upstream raw materials:

trityl chloride

2-hydroxyethanethiol

triphenylmethanethiol

2-bromoethanol

Downstream raw materials:

S-triphenylmethyl O-methoxymorpholinophosphinyl 2-mercaptoethanol

2-hydroxyethanethiol

6-((S)-4-Benzyl-4,5-dihydro-oxazol-2-yl)-nicotinic acid 2-tritylsulfanyl-ethyl ester

2-[2-[2-[(triphenylmethyl)thio]ethoxy]ethoxy]ethanol

Refernces

• 1、 Cooley, Christina B.,Trantow, Brian M.,Nederberg, Fredrik,Kiesewetter, Matthew K.,Hedrick, James L.,Waymouth, Robert M.,Wender, Paul A.. "Oligocarbonate molecular transporters: Oligomerization-based syntheses and cell-penetrating studies". . p. 16401 - 16403. Retrieved 2009.
• 2、 Slor, Gadi,Papo, Nitsan,Hananel, Uri,Amir, Roey J.. "Tuning the molecular weight of polymeric amphiphiles as a tool to access micelles with a wide range of enzymatic degradation rates". supporting information. p. 6875 - 6878. Retrieved 2018/06/26.