1-(4-aminophenyl)isoquinoline

Base Information

• Chemical Name: 1-(4-aminophenyl)isoquinoline
• CAS No.: 58992-84-0
• Molecular Formula: C15H12 N2
• Molecular Weight: 220.274
• Hs Code.: 2933499090
• Mol file: 58992-84-0.mol

Synonyms:1-(4-Aminophenyl)isoquinoline

Chemical Property of 1-(4-aminophenyl)isoquinoline

Chemical Property:

• Vapor Pressure: 2.12E-06mmHg at 25°C
• Boiling Point: 393.5°C at 760 mmHg
• Flash Point: 220.3°C
• PSA: 38.91000
• Density: 1.194g/cm³
• LogP: 4.06520
• Storage Temp.: 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

4-(Isoquinolin-1-yl)aniline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-aminophenyl)isoquinoline

There total 4 articles about 1-(4-aminophenyl)isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.6%

1-(4-nitrophenyl)isoquinoline (86448-89-7) → 4-(isoquinolin-1-yl)benzenamine (58992-84-0)

Guidance literature:

With 5% Pd(II)/C(eggshell); hydrazine hydrate; In ethanol; at 50 ℃; Reflux; Inert atmosphere;

DOI:10.1016/j.dyepig.2009.12.014

Reference yield:

4-bromo-aniline (106-40-1) → 4-(isoquinolin-1-yl)benzenamine (58992-84-0)

Guidance literature:

With n-butyllithium; diethyl ether; Erwaermen mit Isochinolin und mit H₂O, Erhitzen des Reaktionsprodukts in Nitrobenzol;

DOI:10.1021/ja01200a032

Reference yield:

p-nitrophenyl-1 dihydro-3,4 isoquinoleine (62333-69-1) → 4-(isoquinolin-1-yl)benzenamine (58992-84-0)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium / 200 - 260 °C

2: Raney nickel; ethanol / 95 - 100 °C / Hydrogenation

With ethanol; nickel; palladium;

DOI:10.1021/ja01200a032

upstream raw materials:

1-(4-nitrophenyl)isoquinoline

4-bromo-aniline

p-nitrophenyl-1 dihydro-3,4 isoquinoleine

Downstream raw materials:

4-(isoquinolin-1-yl)-N,N-di-p-tolylbenzenamine

4-tert-butyl-N-(4-tert-butylphenyl)-N-(4-(isoquinolin-1-yl)phenyl)benzenamine

Refernces