Saralasin

Base Information

• Chemical Name: Saralasin
• CAS No.: 34273-10-4
• Molecular Formula: C42H65N13O10
• Molecular Weight: 912.059
• DSSTox Substance ID: DTXSID2046549
• Nikkaji Number: J18.486A
• Wikipedia: Saralasin
• Wikidata: Q410298
• NCI Thesaurus Code: C66527
• Pharos Ligand ID: QA6JR3NKFLT2
• Metabolomics Workbench ID: 144346
• ChEMBL ID: CHEMBL938
• Mol file: 34273-10-4.mol

Synonyms:(Sar(1),Ala(8))ANGII;(Sar1,Val5,Ala8)Angiotensin II;1 Sar 8 Ala Angiotensin II;1 Sarcosine 8 Alanine Angiotensin II;1-Sar-8-Ala Angiotensin II;1-Sarcosine-8-Alanine Angiotensin II;Angiotensin II, 1-Sar-8-Ala;Angiotensin II, 1-Sarcosine-8-Alanine;angiotensin II, Sar(1)-Ala(8)-;angiotensin II, sarcosyl(1)-alanine(8)-;Anhydrous Saralasin Acetate;Hydrated Saralasin Acetate;Sar-Arg-Val-Tyr-Val-His-Pro-Ala;Saralasin;Saralasin Acetate;Saralasin Acetate, Anhydrous;Saralasin Acetate, Hydrated

Chemical Property of Saralasin

Chemical Property:

• Appearance/Colour: powder
• Refractive Index: 1.653
• PSA: 355.05000
• Density: 1.42 g/cm³
• LogP: 1.56460
• Storage Temp.: −20°C
• XLogP3: -2.6
• Hydrogen Bond Donor Count: 12
• Hydrogen Bond Acceptor Count: 13
• Rotatable Bond Count: 25
• Exact Mass: 911.49773532
• Heavy Atom Count: 65
• Complexity: 1670

Purity/Quality:

98%,99%, ^*data from raw suppliers

Saralasin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(C(C)C)C(=O)NC(CC2=CN=CN2)C(=O)N3CCCC3C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC
• Isomeric SMILES: C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC
• Uses: Antihypertensive. Saralasin are angiotensin II receptor agonists.

Technology Process of Saralasin

There total 1 articles about Saralasin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ saralasin (34273-10-4)

Guidance literature:

Boc-Sar-Arg-Val-Tyr(tBu)-Val-His-Pro-Ala-OtBu, CF3COOH;

DOI:10.1515/bchm2.1976.357.1.825

Reference yield: 68.0%

diethyl 4-((3r,5r,7r)-adamantan-1-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate + saralasin (34273-10-4) → C52H79N13O10

Guidance literature:

With trifluoroacetic acid; In 2,2,2-trifluoroethanol; at 35 ℃; for 9h; chemospecific reaction; Irradiation; Inert atmosphere; Sealed tube;

DOI:10.1021/jacs.9b09127

Reference yield: 66.0%

diethyl 4-(3-((2,5,8,11-tetraoxatridecan-13-yl)carbamoyl)ada-mantan-1-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate + saralasin (34273-10-4) → C62H98N14O15

Guidance literature:

With trifluoroacetic acid; In 2,2,2-trifluoroethanol; at 35 ℃; for 9h; chemospecific reaction; Irradiation; Inert atmosphere; Sealed tube;

DOI:10.1021/jacs.9b09127

Refernces